1. The document analyzes the seismic behavior of vertically irregular buildings with setbacks compared to regular buildings through response spectrum analysis. 2. 10 building models, including 9 vertically irregular buildings with setbacks and 1 regular building, were analyzed using STAAD.Pro software. 3. The results show that seismic parameters like displacement, story drift, and shear were highest at the setback levels, indicating setbacks weaken building performance during earthquakes. Irregular buildings experienced more severe effects than the regular building.