This document discusses autocorrelation in time series data and its effects on regression analysis. It defines autocorrelation as errors in one time period carrying over into future periods. Autocorrelation can be caused by factors like inertia in economic cycles, specification bias, lags, and nonstationarity. While OLS estimators remain unbiased with autocorrelation, they become inefficient and hypothesis tests are invalid. Autocorrelation can be detected using graphical analysis or formal tests like the Durbin-Watson test and Breusch-Godfrey test. The Cochrane-Orcutt procedure is also described as a way to transform data and remove autocorrelation.