Abstract In India reinforced concrete structures are mostly used since this is the most convenient & economic system for low-rise buildings. However, for medium to high-rise buildings this type of structure is no longer economic because of increased dead load, less stiffness, span restriction and hazardous formwork. So the Structural engineers are facing the challenge of striving for the most efficient and economical design solution. Also Earthquake engineering should be extended to the design of earthquake sensitive tall buildings. Use of composite material is of particular interest, due to its significant potential in improving the overall performance through rather modest changes in manufacturing and constructional technologies. In India, many consulting engineers are reluctant to accept the use of composite steel-concrete structure because of its unfamiliarity and complexity in its analysis and design. But literature says that if properly configured, then composite steel-concrete system can provide extremely economical structural systems with high durability, rapid erection and superior seismic performance characteristics. This paper discusses Optimization of Earth quack response of tall building by using different types of framing system over the height of the building . So to optimize the earth quack response, a Ten story Combined model ( R.C.C, Composite and Steel frames) is developed and analyzed by using ETABS ; it proves that the combined model is better option. Key Words: Composite structure, Tall Building and Steel structures