A Newcastle disease outbreak occurred in Region III of the Philippines in early 2016 following typhoons in late 2015. Over 400,000 backyard chickens died as the highly contagious virus spread across the 7 provinces. In response, meetings were held with stakeholders, surveillance increased, an education campaign launched, over 1 million vaccine doses distributed and administered to 238,204 birds, quarantine checkpoints established, and a regional response team created through collaboration between the Department of Agriculture, Bureau of Animal Industry, and Central Luzon State University. Coordinated control efforts successfully contained the outbreak by the end of April 2016 with no further significant cases reported.