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Case 1. Animal Rabies
Background:
In 2007, Republic Act No. 9482 or the Anti-Rabies Act of 2007 was approved to strengthen
the political and legal basis of the national program for the control and Elimination of Human
and Animal Rabies.
To ensure implementation, the National Rabies Prevention and Control Committee (NRPCC)
was organized. This body is chaired by DA Bureau of Animal industry and co-chaired by
DOH Disease Prevention and Control Bureau. Other members come from the Department of
Interior and Local Government, Department of Education, Department of Environment and
Natural Resources, NGOs; People’s Organizations; Academe; and Local Government Units
(LGUs) of the Philippines.
The problem on the supply of vaccines was resolved through a 2014 Memorandum of
Agreement (MOA) which stipulates the transfer of Department of Health (DOH) funds to the
Department of Agriculture (DA) for procurement of rabies vaccines.
Animal Rabies cases from 2005 to 2015
Group discussion:
1. What is your observation regarding the graph shown above?
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
2. Enumerate several reasons why animal rabies persists in the Philippines:
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
3. List recommendations to accelerate the elimination of rabies by 2020:
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
1
Case Study 2: Newcastle Disease in commercial farms
(Reference article: to be issued after the exercise)
Background:
Newcastle disease (ND) is one of the most important diseases of poultry, and may cause
devastating losses in the poultry industry worldwide. Its causative agent is Newcastle
disease virus (NDV), also known as avian paramyxovirus type 1. It has been argued that this
may be due to antigenic divergence between the vaccine strains and circulating field strains.
Research question:
Can a classic vaccine protect chickens from ND strain isolated from a recent outbreak?
Research results:
1. The researchers were able to present the complete genome sequence of a highly
virulent genotype VII virus (NL/93) obtained from an outbreak of ND;
2. The manufactured live vaccine that is antigenically adapted to match the genotype
VII NL/93 outbreak strain does not provide increased protection compared to a
classic genotype II live vaccine.
3. When challenged with the NL/93 strain, chickens vaccinated with a classic vaccine
were completely protected against clinical disease and mortality and virus shedding
was significantly reduced, even with a supposedly suboptimal vaccine dose.
Conclusion:
The outbreaks and spreading of virulent NDV field strains is not due to antigenic variation.
Group discussion:
1. If it is not due to a ND new strain, enumerate and explain the possible causes of ND
outbreak in a commercial poultry farm with regular ND vaccination.
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
2. What are the specific activities that must be undertaken to prevent and control ND
outbreaks in commercial farms?
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
2
Case Study 3: Newcastle Disease in backyard farms
(Reference article: to be issued after the exercise)
Background:
Newcastle disease (ND) is one of the most important diseases of poultry, and may cause
devastating losses in the poultry industry worldwide. Its causative agent is Newcastle
disease virus (NDV), also known as avian paramyxovirus type 1. It has been argued that this
may be due to antigenic divergence between the vaccine strains and circulating field strains.
Research question:
Can a classic vaccine protect chickens from ND strain isolated from a recent outbreak?
Research results:
4. The researchers were able to present the complete genome sequence of a highly
virulent genotype VII virus (NL/93) obtained from an outbreak of ND;
5. The manufactured live vaccine that is antigenically adapted to match the genotype
VII NL/93 outbreak strain does not provide increased protection compared to a
classic genotype II live vaccine.
6. When challenged with the NL/93 strain, chickens vaccinated with a classic vaccine
were completely protected against clinical disease and mortality and virus shedding
was significantly reduced, even with a supposedly suboptimal vaccine dose.
Conclusion:
The outbreaks and spreading of virulent NDV field strains is not due to antigenic variation.
Group discussion:
3. If it is not due to a ND new strain, enumerate and explain the possible causes of ND
outbreak in chickens owned by backyard and gamefowl farmers?
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
4. What are the specific activities that must be undertaken to prevent and control ND
outbreaks in backyard and gamefowl farms?
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
3
Case Study 4: Schistosomiasis (SCH)
Background:
SCH is endemic in 12 regions, 28 provinces, 190 municipalities, 15 cities, and approximately
2,230 barangays (WHO, 2012) in the Philippines. It is estimated that 12 million Filipinos are
at risk of acquiring SCH, while 2.5 million have already been exposed (DOH, 2012). The
Schistosomaisis Control and Elimination Program (SCEP) aims to reduce disease through
periodic, large-scale human population treatment using the drug Praziquantel. The latest
provincial accomplishment range from 26.2-96.8% (DOH, 2014). However, SCH is focally
transmitted and some provinces such as Samar Island and Negros Occidental still show a
prevalence rate as high as 69% at barangay level (2012).
Previous Investigation
Prevalence of Schistosoma japonicum Infection in Animals in some
Endemic Barangays of Western Samar
Animals Prevalence
Rats 95.4
Dogs 86.3
Buffalo 72.5
Cats 21.7
Pigs 18.4
Source: (T.J. Fernandez, Jr., A.L. Willingham, S. McGarvey, H. Carabin, R.M.
Molveda &E. Balolong. 2005).
1. Enumerate and explain the possible causes of persistence of schistosomiasis in the
Philippines
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
2. What are the specific activities that must be undertaken to reduce the prevalence
level of Schistosomiasis in Western Samar?
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
4
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
5
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
• _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _
5

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Disease Occurence or Persistence

  • 1. Case 1. Animal Rabies Background: In 2007, Republic Act No. 9482 or the Anti-Rabies Act of 2007 was approved to strengthen the political and legal basis of the national program for the control and Elimination of Human and Animal Rabies. To ensure implementation, the National Rabies Prevention and Control Committee (NRPCC) was organized. This body is chaired by DA Bureau of Animal industry and co-chaired by DOH Disease Prevention and Control Bureau. Other members come from the Department of Interior and Local Government, Department of Education, Department of Environment and Natural Resources, NGOs; People’s Organizations; Academe; and Local Government Units (LGUs) of the Philippines. The problem on the supply of vaccines was resolved through a 2014 Memorandum of Agreement (MOA) which stipulates the transfer of Department of Health (DOH) funds to the Department of Agriculture (DA) for procurement of rabies vaccines. Animal Rabies cases from 2005 to 2015 Group discussion: 1. What is your observation regarding the graph shown above? • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 2. Enumerate several reasons why animal rabies persists in the Philippines: • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 3. List recommendations to accelerate the elimination of rabies by 2020: • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 1
  • 2. Case Study 2: Newcastle Disease in commercial farms (Reference article: to be issued after the exercise) Background: Newcastle disease (ND) is one of the most important diseases of poultry, and may cause devastating losses in the poultry industry worldwide. Its causative agent is Newcastle disease virus (NDV), also known as avian paramyxovirus type 1. It has been argued that this may be due to antigenic divergence between the vaccine strains and circulating field strains. Research question: Can a classic vaccine protect chickens from ND strain isolated from a recent outbreak? Research results: 1. The researchers were able to present the complete genome sequence of a highly virulent genotype VII virus (NL/93) obtained from an outbreak of ND; 2. The manufactured live vaccine that is antigenically adapted to match the genotype VII NL/93 outbreak strain does not provide increased protection compared to a classic genotype II live vaccine. 3. When challenged with the NL/93 strain, chickens vaccinated with a classic vaccine were completely protected against clinical disease and mortality and virus shedding was significantly reduced, even with a supposedly suboptimal vaccine dose. Conclusion: The outbreaks and spreading of virulent NDV field strains is not due to antigenic variation. Group discussion: 1. If it is not due to a ND new strain, enumerate and explain the possible causes of ND outbreak in a commercial poultry farm with regular ND vaccination. • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 2. What are the specific activities that must be undertaken to prevent and control ND outbreaks in commercial farms? • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 2
  • 3. Case Study 3: Newcastle Disease in backyard farms (Reference article: to be issued after the exercise) Background: Newcastle disease (ND) is one of the most important diseases of poultry, and may cause devastating losses in the poultry industry worldwide. Its causative agent is Newcastle disease virus (NDV), also known as avian paramyxovirus type 1. It has been argued that this may be due to antigenic divergence between the vaccine strains and circulating field strains. Research question: Can a classic vaccine protect chickens from ND strain isolated from a recent outbreak? Research results: 4. The researchers were able to present the complete genome sequence of a highly virulent genotype VII virus (NL/93) obtained from an outbreak of ND; 5. The manufactured live vaccine that is antigenically adapted to match the genotype VII NL/93 outbreak strain does not provide increased protection compared to a classic genotype II live vaccine. 6. When challenged with the NL/93 strain, chickens vaccinated with a classic vaccine were completely protected against clinical disease and mortality and virus shedding was significantly reduced, even with a supposedly suboptimal vaccine dose. Conclusion: The outbreaks and spreading of virulent NDV field strains is not due to antigenic variation. Group discussion: 3. If it is not due to a ND new strain, enumerate and explain the possible causes of ND outbreak in chickens owned by backyard and gamefowl farmers? • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 4. What are the specific activities that must be undertaken to prevent and control ND outbreaks in backyard and gamefowl farms? • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 3
  • 4. Case Study 4: Schistosomiasis (SCH) Background: SCH is endemic in 12 regions, 28 provinces, 190 municipalities, 15 cities, and approximately 2,230 barangays (WHO, 2012) in the Philippines. It is estimated that 12 million Filipinos are at risk of acquiring SCH, while 2.5 million have already been exposed (DOH, 2012). The Schistosomaisis Control and Elimination Program (SCEP) aims to reduce disease through periodic, large-scale human population treatment using the drug Praziquantel. The latest provincial accomplishment range from 26.2-96.8% (DOH, 2014). However, SCH is focally transmitted and some provinces such as Samar Island and Negros Occidental still show a prevalence rate as high as 69% at barangay level (2012). Previous Investigation Prevalence of Schistosoma japonicum Infection in Animals in some Endemic Barangays of Western Samar Animals Prevalence Rats 95.4 Dogs 86.3 Buffalo 72.5 Cats 21.7 Pigs 18.4 Source: (T.J. Fernandez, Jr., A.L. Willingham, S. McGarvey, H. Carabin, R.M. Molveda &E. Balolong. 2005). 1. Enumerate and explain the possible causes of persistence of schistosomiasis in the Philippines • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 2. What are the specific activities that must be undertaken to reduce the prevalence level of Schistosomiasis in Western Samar? • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 4
  • 5. • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 5
  • 6. • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ • _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 5
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