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M U H A M M A D A K R A M M U N I R
( a k r a m m u n e e r @ h o t m a i l . c o m )
R A S H I D A H M A D
D A N Y A L H A S A N
R A F I Q U E H A S H M I
R C V E T S , L A H O R E
Strategies for Controlling
Infectious Livestock Diseases
Strategy
 A plan of actions to achieve a long term
objective/aim
 Designed to achieve the goals of a department or an
organization
Infectious Diseases
 Diseases caused by microorganisms like bacteria,
viruses, fungi, etc.
 Infection: Invasion and growth of microorganisms
in body of host (man, animals, poultry, fish etc.)
 Disease: Dis-ease occurs when the body cells are
damaged as a result of infection and ultimately lead
to signs and symptoms of illness
Infectious Diseases
An illness due to a pathogen or its toxic products.
Usually transmitted from an infected animal/person,
to any susceptible host or population. Examples NDV,
AI, HS, Rabies, Covid-19 etc.
 Emerging Infectious Disease:
Newly discovered infectious agents.
 Re-emerging Infectious Disease:
Which was previously controlled but once again
has risen to be a significant health problem
Livestock
 The animals kept for profit purpose
 Mostly the farm animals are known as livestock
 They are distinguish from other animal types as they
are domesticated and mostly raised for food and
money sources
 Livestock products are meat, milk, eggs and skins
hides etc.
Infectious Livestock Diseases
Bacterial Viral Parasitic
• Colibacillosis
• Anthrax
• Tuberculosis
• Salmollelosis
• Listeriosis
• Fowl Cholera
• SARS
• Avian Influenza
• Lumpy Skin Disease
• EBOLA
• Foot and Mouth
• New castle
• Rabies
• Trypanosomiasis
• Babesiosis
• Theileriosis
• Piroplasmosis
• Spirochetosis
• Lice, Fleas, Ticks etc.
• Worms
Disease Contributing Factors
 Climate and weather
 Change Ecosystem
 Microbial adaptation and changes
 Economic Development and Land use
 Technology and Industry
 Breakdown of Public Health Measures
 Poverty and social inequality
 Human susceptibility of Infections
 International travel and commerce
Zoonotic Diseases
 Diseases transmitted between man and animals and
vice versa such as:
 Rabies
 CCHF
 Blastomycosis
 Psittacosis
 Trichinella spiralis
 Salmonellosis
Bio-terrorism Diseases
 Anthrax
 Plague
 Brucellosis
 Q fever (Caused by Coxiella burnettii)
Types of Infectious Diseases
 Sporadic
 Endemic
 Epidemic
 Pandemic
 AGENT:
1-Evolution of pathogenic infectious agents
(Microbial adaptation and change)
2-Development of resistance to drugs: wrong
prescribing practice
3-Resistance of vectors to pesticides
Factor Contributing to Emergence
Factor Contributing to Emergence
 HOST:
1-Demographic change
2-Increased international travel
3-Immunosuppression
Important Epidemiological Factors
Important Epidemiological Factors
 Epidemiology: Study of disease occurrence in animal
and human population
 Virology: Study of viruses causing infectious diseases
 Bacteriology: Study of bacteria causing infectious
diseases
 Mycology: Study of fungi causing infectious diseases
 Immunology: Study of immune reactions in hosts and
conferring of resistance against infectious diseases
 Public Health: Study of various factors contributing to
infectious disease in host; host virus interactions, disease
diagnosis, etc.
Control Strategies
 Develop political will and funding
 Improve global early response capacity
a. WHO,
b. National Disease Control Unit and Training
Program
 Improve Global Surveillance
a. Improve diagnostic capacity
b. Improve communication system and shearing of
surveillance data
c. Rapid Data analysis
d. Develop innovative surveillance and analysis strategies
Disease Control Contributors
 Will to control or prevent infectious diseases at local,
regional, country or global level
 Cooperation and coordination amongst
professionals, livestock owners, and workers
 A multi-disciplinary coordination
 Cooperation of Scientists, Veterinarians, public at
large, politicians, farmers, planners, financing
agencies, etc.
 Cooperation of agencies like FAO, WHO, OIE, JICA,
USAID, AUSAID,
Practical Approaches on Disease Control
 Registration of animal populations
 Diagnosis: Clinical, laboratory, confirmatory
 Epidemiological investigations, type and magnitude of
population involvement
 Economical, zoonotic importance of disease
 Effective disease control measures:
1. Treatment of sick populations using antibiotics,
antivirals, antisera etc.
2. Use of vaccines, live, killed, or both, genetically
engineered, sub-unit, etc.
Practical Approaches on Disease Control
 Isolation and quarantine of sick populations
 Developing disease free zones, ban on sick animal
movements
 In case of contagious and deadly disease; humane slaughter
and disposal of infected and exposed animals.
 Training of animal owners on animal hygiene, premises
cleaning, and disinfection
 Development of new effective drugs against pathogens
 Vector control, movement control of animals and humans
working with animals
 Bio-control measures
 Emerging use of bio-technology in diagnosis, vaccine
development
Key factors in control
 Disease awareness amongst livestock owners,
professionals, extension owners, lab workers, ,
personnel responsible for infectious waste material,
etc.
 Surveillance and infection behavior in a population
 Coordination/cooperation amongst various
government functionaries
Key Factors in Control
 Potential for infectious disease diagnosis;
 labs equipped with the state of the art facilities;
 especially the infectious material dealing,
 processing and preservation of material in lab,
 qualifications and training of lab staff,
 result interpretation, prevention of
contamination of lab premises,
 availability of bio-secure and biosafe
environment, etc.
Key Factors in Control
 1. Reporting system: To whom to report and how
 2. How to sample infectious material
 3. How to convince farmer for his cooperation;
 as per legislation;
 treatment requirements, payment of compensation to
farmers in case of high morbidity and mortality,
 disposal of contagious disease infected carcasses,
monitoring for positives cases, premises, samples etc.
 Training activities
Vector Control
 a program to control and eliminate these
vectors will be implemented to stop the
method of transmission (such as
arthropods, rodents, or other vectors).
 Before a vector control program is
initiated, several factors will be considered,
including the biological characteristics and
population density of the vector species
involved;
Vector Control
 methods and materials available for
control and eradication; and the
potential impact on the environment.
 The use of certain pesticides
may require an environmental
impact statement.
Role of Veterinarians in Prevention
Increase knowledge and skill ; Educate the public
Encourage partnerships with consumers and other
disciplines to identify needs, set priorities, develop
strategies and evaluate progress
Support health care legislation
Involve in research
Encourage using multidisciplinary efforts.
Influence local and National economic and political
options
Continue to advance nursing concern
Role of Public Health Authorities
 National program for prevention and control of
vector borne diseases
 Legislations for elimination
 Communities awareness of the disease
 Minimizing transmission of infection: By
• Risk communication to the family members
• Minimizing vector population
• Minimizing vector – individual contact
 Reporting to the nearest public health authority
Public health Measures to Prevent
Infectious Diseases
 Safe water
 Sewage treatment and disposal
 Food safety program
 Animal control program
 Vaccination program
 Public health organization
Preventive Strategy in Pakistan
 VECTOR SURVEILLANCE
 Vector borne epidemic prone diseases: JE, Dengue,
Plague, Kala-azar, Rickettsia
 Early warning signals - increase density of vectors -
increase in breeding sites for vectors
 Insecticide susceptibility status
 To assess impact of routine measures under national
program
Lab Surveillance
 Serological Surveillance
 To collect baseline prevalence data
 To identify high risk areas
 To identify high risk age group As early warning
signal for impending outbreak
 Microbial surveillance
Changing genotype
Mutations
Development of Antimicrobial Resistance Eg.
Salmonella, Cholera, Plague, Anthrax
Diagnostic Procedures
 PCR (The sensitive detection of pathogenic
microorganisms by amplification of gene fragments)
 ELISA (to measure antibodies, antigens, proteins
and glycoproteins in biological samples.)
 NASBA (which amplifies RNA for the detection of
microbial pathogens)
 Fingerprinting ( method of isolating and
identifying variable elements within the base-pair
sequence of DNA)
Diagnostic Procedures
 LCR ( Ligase Chain Reaction)
(For the detection of single base mutations, as in
genetic diseases)
 Western Bloat (to detect specific protein
molecules from among a mixture of proteins.)
 Northern Bloat (to detect specific RNA molecules
among a mixture of RNA.)
Laboratories Network in Surveillance
 International (Collaborating Centers) like CDC
Atlanta
 National Reference Laboratories e.g. NVL
Islamabad, NARC Islamabad, VRI Lahore, BRI
Pattoki
 State laboratories
 Intermediate (District/Provincial/Medical College)
 Peripheral Laboratories
NPCPAI
 Scale up AI surveillance, diagnostics at district,
provincial and federal level
 Strengthen disease control, outbreak containment,
and eradication of HPAI
 Increase awareness among farmers, consumers,
veterinarians, and other stake holders on AI
epidemiology
 Undertaking AI vaccine research; ecology,
pathogenesis, diagnostics, and vaccine development
NPCPAI
 Strengthen AI vaccine production, its evaluation and
quality assurance
 Develop a legal and regulatory frame work for
veterinary services providers and to empower the
government function to enforce national animal
disease control measures
 Outcome
 AI H5N1 AI outbreaks under control
THANKS

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Controlling infectious diseases

  • 1. M U H A M M A D A K R A M M U N I R ( a k r a m m u n e e r @ h o t m a i l . c o m ) R A S H I D A H M A D D A N Y A L H A S A N R A F I Q U E H A S H M I R C V E T S , L A H O R E Strategies for Controlling Infectious Livestock Diseases
  • 2. Strategy  A plan of actions to achieve a long term objective/aim  Designed to achieve the goals of a department or an organization
  • 3. Infectious Diseases  Diseases caused by microorganisms like bacteria, viruses, fungi, etc.  Infection: Invasion and growth of microorganisms in body of host (man, animals, poultry, fish etc.)  Disease: Dis-ease occurs when the body cells are damaged as a result of infection and ultimately lead to signs and symptoms of illness
  • 4. Infectious Diseases An illness due to a pathogen or its toxic products. Usually transmitted from an infected animal/person, to any susceptible host or population. Examples NDV, AI, HS, Rabies, Covid-19 etc.
  • 5.  Emerging Infectious Disease: Newly discovered infectious agents.  Re-emerging Infectious Disease: Which was previously controlled but once again has risen to be a significant health problem
  • 6. Livestock  The animals kept for profit purpose  Mostly the farm animals are known as livestock  They are distinguish from other animal types as they are domesticated and mostly raised for food and money sources  Livestock products are meat, milk, eggs and skins hides etc.
  • 7. Infectious Livestock Diseases Bacterial Viral Parasitic • Colibacillosis • Anthrax • Tuberculosis • Salmollelosis • Listeriosis • Fowl Cholera • SARS • Avian Influenza • Lumpy Skin Disease • EBOLA • Foot and Mouth • New castle • Rabies • Trypanosomiasis • Babesiosis • Theileriosis • Piroplasmosis • Spirochetosis • Lice, Fleas, Ticks etc. • Worms
  • 8. Disease Contributing Factors  Climate and weather  Change Ecosystem  Microbial adaptation and changes  Economic Development and Land use  Technology and Industry  Breakdown of Public Health Measures  Poverty and social inequality  Human susceptibility of Infections  International travel and commerce
  • 9. Zoonotic Diseases  Diseases transmitted between man and animals and vice versa such as:  Rabies  CCHF  Blastomycosis  Psittacosis  Trichinella spiralis  Salmonellosis
  • 10. Bio-terrorism Diseases  Anthrax  Plague  Brucellosis  Q fever (Caused by Coxiella burnettii)
  • 11. Types of Infectious Diseases  Sporadic  Endemic  Epidemic  Pandemic
  • 12.  AGENT: 1-Evolution of pathogenic infectious agents (Microbial adaptation and change) 2-Development of resistance to drugs: wrong prescribing practice 3-Resistance of vectors to pesticides Factor Contributing to Emergence
  • 13. Factor Contributing to Emergence  HOST: 1-Demographic change 2-Increased international travel 3-Immunosuppression
  • 15. Important Epidemiological Factors  Epidemiology: Study of disease occurrence in animal and human population  Virology: Study of viruses causing infectious diseases  Bacteriology: Study of bacteria causing infectious diseases  Mycology: Study of fungi causing infectious diseases  Immunology: Study of immune reactions in hosts and conferring of resistance against infectious diseases  Public Health: Study of various factors contributing to infectious disease in host; host virus interactions, disease diagnosis, etc.
  • 16. Control Strategies  Develop political will and funding  Improve global early response capacity a. WHO, b. National Disease Control Unit and Training Program  Improve Global Surveillance a. Improve diagnostic capacity b. Improve communication system and shearing of surveillance data c. Rapid Data analysis d. Develop innovative surveillance and analysis strategies
  • 17. Disease Control Contributors  Will to control or prevent infectious diseases at local, regional, country or global level  Cooperation and coordination amongst professionals, livestock owners, and workers  A multi-disciplinary coordination  Cooperation of Scientists, Veterinarians, public at large, politicians, farmers, planners, financing agencies, etc.  Cooperation of agencies like FAO, WHO, OIE, JICA, USAID, AUSAID,
  • 18. Practical Approaches on Disease Control  Registration of animal populations  Diagnosis: Clinical, laboratory, confirmatory  Epidemiological investigations, type and magnitude of population involvement  Economical, zoonotic importance of disease  Effective disease control measures: 1. Treatment of sick populations using antibiotics, antivirals, antisera etc. 2. Use of vaccines, live, killed, or both, genetically engineered, sub-unit, etc.
  • 19. Practical Approaches on Disease Control  Isolation and quarantine of sick populations  Developing disease free zones, ban on sick animal movements  In case of contagious and deadly disease; humane slaughter and disposal of infected and exposed animals.  Training of animal owners on animal hygiene, premises cleaning, and disinfection  Development of new effective drugs against pathogens  Vector control, movement control of animals and humans working with animals  Bio-control measures  Emerging use of bio-technology in diagnosis, vaccine development
  • 20. Key factors in control  Disease awareness amongst livestock owners, professionals, extension owners, lab workers, , personnel responsible for infectious waste material, etc.  Surveillance and infection behavior in a population  Coordination/cooperation amongst various government functionaries
  • 21. Key Factors in Control  Potential for infectious disease diagnosis;  labs equipped with the state of the art facilities;  especially the infectious material dealing,  processing and preservation of material in lab,  qualifications and training of lab staff,  result interpretation, prevention of contamination of lab premises,  availability of bio-secure and biosafe environment, etc.
  • 22. Key Factors in Control  1. Reporting system: To whom to report and how  2. How to sample infectious material  3. How to convince farmer for his cooperation;  as per legislation;  treatment requirements, payment of compensation to farmers in case of high morbidity and mortality,  disposal of contagious disease infected carcasses, monitoring for positives cases, premises, samples etc.  Training activities
  • 23. Vector Control  a program to control and eliminate these vectors will be implemented to stop the method of transmission (such as arthropods, rodents, or other vectors).  Before a vector control program is initiated, several factors will be considered, including the biological characteristics and population density of the vector species involved;
  • 24. Vector Control  methods and materials available for control and eradication; and the potential impact on the environment.  The use of certain pesticides may require an environmental impact statement.
  • 25. Role of Veterinarians in Prevention Increase knowledge and skill ; Educate the public Encourage partnerships with consumers and other disciplines to identify needs, set priorities, develop strategies and evaluate progress Support health care legislation Involve in research Encourage using multidisciplinary efforts. Influence local and National economic and political options Continue to advance nursing concern
  • 26. Role of Public Health Authorities  National program for prevention and control of vector borne diseases  Legislations for elimination  Communities awareness of the disease  Minimizing transmission of infection: By • Risk communication to the family members • Minimizing vector population • Minimizing vector – individual contact  Reporting to the nearest public health authority
  • 27. Public health Measures to Prevent Infectious Diseases  Safe water  Sewage treatment and disposal  Food safety program  Animal control program  Vaccination program  Public health organization
  • 28. Preventive Strategy in Pakistan  VECTOR SURVEILLANCE  Vector borne epidemic prone diseases: JE, Dengue, Plague, Kala-azar, Rickettsia  Early warning signals - increase density of vectors - increase in breeding sites for vectors  Insecticide susceptibility status  To assess impact of routine measures under national program
  • 29. Lab Surveillance  Serological Surveillance  To collect baseline prevalence data  To identify high risk areas  To identify high risk age group As early warning signal for impending outbreak  Microbial surveillance Changing genotype Mutations Development of Antimicrobial Resistance Eg. Salmonella, Cholera, Plague, Anthrax
  • 30. Diagnostic Procedures  PCR (The sensitive detection of pathogenic microorganisms by amplification of gene fragments)  ELISA (to measure antibodies, antigens, proteins and glycoproteins in biological samples.)  NASBA (which amplifies RNA for the detection of microbial pathogens)  Fingerprinting ( method of isolating and identifying variable elements within the base-pair sequence of DNA)
  • 31. Diagnostic Procedures  LCR ( Ligase Chain Reaction) (For the detection of single base mutations, as in genetic diseases)  Western Bloat (to detect specific protein molecules from among a mixture of proteins.)  Northern Bloat (to detect specific RNA molecules among a mixture of RNA.)
  • 32. Laboratories Network in Surveillance  International (Collaborating Centers) like CDC Atlanta  National Reference Laboratories e.g. NVL Islamabad, NARC Islamabad, VRI Lahore, BRI Pattoki  State laboratories  Intermediate (District/Provincial/Medical College)  Peripheral Laboratories
  • 33. NPCPAI  Scale up AI surveillance, diagnostics at district, provincial and federal level  Strengthen disease control, outbreak containment, and eradication of HPAI  Increase awareness among farmers, consumers, veterinarians, and other stake holders on AI epidemiology  Undertaking AI vaccine research; ecology, pathogenesis, diagnostics, and vaccine development
  • 34. NPCPAI  Strengthen AI vaccine production, its evaluation and quality assurance  Develop a legal and regulatory frame work for veterinary services providers and to empower the government function to enforce national animal disease control measures  Outcome  AI H5N1 AI outbreaks under control
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