CLASSIFICATION OF H1 ANTIHISTAMINICS-
FIRST GENERATION ANTIHISTAMINICS-
1)HIGHLY SEDATIVE-DIPHENHYDRAMINE,DIMENHYDRINATE,PROMETHAZINE,HYDROXYZINE 2)MODERATELY SEDATIVE- PHENARIMINE,CYPROHEPTADINE, MECLIZINE,CINNARIZINE
3)MILD SEDATIVE-CHLORPHENIRAMINE,DEXCHLORPHENIRAMINE
TRIPROLIDINE,CLEMASTINE
SECOND GENERATION ANTIHISTAMINICS-FEXOFENADINE,
LORATADINE,DESLORATADINE,CETIRIZINE,LEVOCETIRIZINE,
AZELASTINE,MIZOLASTINE,EBASTINE,RUPATADINE. Mechanism of action of 2nd generation antihistaminics-
These drugs competitively antagonize actions of
histamine at the H1 receptors.
Pharmacological actions-
Antagonism of histamine-The H1 antagonists effectively block histamine induced bronchoconstriction, contraction of intestinal and other smooth muscle and triple response especially wheal, flare and itch. Constriction of larger blood vessel by histamine is also antagonized.
2) Antiallergic actions-Many manifestations of immediate hypersensitivity (type I reactions)are suppressed. Urticaria, itching and angioedema are well controlled.3) CNS action-The older antihistamines produce variable degree of CNS depression.But in case of 2nd gen antihistaminics there is less CNS depressant property as these cross BBB to significantly lesser extent.
4) Anticholinergic action- many H1 blockers
in addition antagonize muscarinic actions of ACh. BUT IN 2ND gen histaminics there is Higher H1 selectivitiy : no anticholinergic side effects
SSRIs and SNRIs are commonly used to treat depression. SSRIs work by blocking the reuptake of serotonin, increasing levels of the neurotransmitter in the brain. Common SSRIs include fluoxetine, paroxetine, sertraline, and citalopram. SNRIs like venlafaxine also block the reuptake of serotonin and norepinephrine. These drugs are generally well-tolerated but side effects may include nausea, insomnia, sexual dysfunction, and agitation. Guidelines recommend SSRIs as first-line treatment for moderate to severe depression.
Brand name : NAMENDA
US FDA Approval :October 2003
NMDA (N-methyl-D-aspartate) receptor antagonist
Indicated for the treatment of moderate to severe Alzheimer’s Disease
Methylprednisolone 4 mg tablets smpc taj pharmaceuticalsTaj Pharma
This document is the summary of product characteristics (SMPC) for methylprednisolone 4 mg tablets produced by Taj Pharmaceuticals. It provides information on the pharmaceutical form, clinical uses, posology, contraindications, and warnings for methylprednisolone. The drug is indicated for conditions requiring glucocorticoid activity, including autoimmune, rheumatic, dermatological, ophthalmic, respiratory, and hematological disorders. It lists recommended initial daily dosages for various conditions. Contraindications include infections and hypersensitivity. Warnings cover immunosuppressive effects and increased infection risk, endocrine effects like adrenal suppression, and metabolic effects such as worsening diabetes.
The document discusses SSRIs and SNRIs as treatments for depression. It provides information on:
- How SSRIs and SNRIs work to increase serotonin and norepinephrine levels in the brain through inhibiting reuptake.
- Examples of common SSRIs and SNRIs including citalopram, escitalopram, fluoxetine, sertraline, duloxetine, and venlafaxine.
- Typical dosing ranges and side effects of various antidepressants.
- Special considerations for using antidepressants in certain patient populations and medical conditions.
- Guidelines from studies and organizations like NICE on treating depression and anxiety with antidepressants.
This document provides information on various antidepressant medications, including tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRs). It lists several TCAs and SSRIs, and then provides details for each individual drug, including brand names, dosage forms, strengths, manufacturers, indications, contraindications, half-lives, and dosing information. The document is intended to educate about different antidepressant options and their proper use and dosing.
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Promethazine hydrochloride Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Promethazine hydrochloride Dosage & Rx Info | Promethazine hydrochloride Uses, Side Effects -: Indications, Side Effects, Warnings, Promethazine hydrochloride - Drug Information - Taj Pharma, Promethazine hydrochloride dose Taj pharmaceuticals Promethazine hydrochloride interactions, Taj Pharmaceutical Promethazine hydrochloride contraindications, Promethazine hydrochloride price, Promethazine hydrochloride Taj Pharma Promethazine hydrochloride 10 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Promethazine hydrochloride Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
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Prednisolone Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Prednisolone Dosage & Rx Info | Prednisolone Uses, Side Effects -: Indications, Side Effects, Warnings, Prednisolone - Drug Information - Taj Pharma, Prednisolone dose Taj pharmaceuticals Prednisolone interactions, Taj Pharmaceutical Prednisolone contraindications, Prednisolone price, Prednisolone Taj Pharma Prednisolone 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Prednisolone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
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Trihexyphenidyl - Drug Information - Taj Pharma, Trihexyphenidyl dose Taj pharmaceuticals Trihexyphenidyl interactions, Taj Pharmaceutical Trihexyphenidyl contraindications, Trihexyphenidyl price, Trihexyphenidyl Taj Pharma Trihexyphenidyl Tablets 5mg SMPC- Taj Pharma . Stay connected to all updated on Trihexyphenidyl Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
SSRIs and SNRIs are commonly used to treat depression. SSRIs work by blocking the reuptake of serotonin, increasing levels of the neurotransmitter in the brain. Common SSRIs include fluoxetine, paroxetine, sertraline, and citalopram. SNRIs like venlafaxine also block the reuptake of serotonin and norepinephrine. These drugs are generally well-tolerated but side effects may include nausea, insomnia, sexual dysfunction, and agitation. Guidelines recommend SSRIs as first-line treatment for moderate to severe depression.
Brand name : NAMENDA
US FDA Approval :October 2003
NMDA (N-methyl-D-aspartate) receptor antagonist
Indicated for the treatment of moderate to severe Alzheimer’s Disease
Methylprednisolone 4 mg tablets smpc taj pharmaceuticalsTaj Pharma
This document is the summary of product characteristics (SMPC) for methylprednisolone 4 mg tablets produced by Taj Pharmaceuticals. It provides information on the pharmaceutical form, clinical uses, posology, contraindications, and warnings for methylprednisolone. The drug is indicated for conditions requiring glucocorticoid activity, including autoimmune, rheumatic, dermatological, ophthalmic, respiratory, and hematological disorders. It lists recommended initial daily dosages for various conditions. Contraindications include infections and hypersensitivity. Warnings cover immunosuppressive effects and increased infection risk, endocrine effects like adrenal suppression, and metabolic effects such as worsening diabetes.
The document discusses SSRIs and SNRIs as treatments for depression. It provides information on:
- How SSRIs and SNRIs work to increase serotonin and norepinephrine levels in the brain through inhibiting reuptake.
- Examples of common SSRIs and SNRIs including citalopram, escitalopram, fluoxetine, sertraline, duloxetine, and venlafaxine.
- Typical dosing ranges and side effects of various antidepressants.
- Special considerations for using antidepressants in certain patient populations and medical conditions.
- Guidelines from studies and organizations like NICE on treating depression and anxiety with antidepressants.
This document provides information on various antidepressant medications, including tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRs). It lists several TCAs and SSRIs, and then provides details for each individual drug, including brand names, dosage forms, strengths, manufacturers, indications, contraindications, half-lives, and dosing information. The document is intended to educate about different antidepressant options and their proper use and dosing.
Promethazine 10 mg tablets smpc taj pharmaceuticalsTaj Pharma
Promethazine hydrochloride Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Promethazine hydrochloride Dosage & Rx Info | Promethazine hydrochloride Uses, Side Effects -: Indications, Side Effects, Warnings, Promethazine hydrochloride - Drug Information - Taj Pharma, Promethazine hydrochloride dose Taj pharmaceuticals Promethazine hydrochloride interactions, Taj Pharmaceutical Promethazine hydrochloride contraindications, Promethazine hydrochloride price, Promethazine hydrochloride Taj Pharma Promethazine hydrochloride 10 mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Promethazine hydrochloride Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
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Prednisolone Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Prednisolone Dosage & Rx Info | Prednisolone Uses, Side Effects -: Indications, Side Effects, Warnings, Prednisolone - Drug Information - Taj Pharma, Prednisolone dose Taj pharmaceuticals Prednisolone interactions, Taj Pharmaceutical Prednisolone contraindications, Prednisolone price, Prednisolone Taj Pharma Prednisolone 10mg Tablets SMPC- Taj Pharma . Stay connected to all updated on Prednisolone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
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IMIPRAMINE Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, IMIPRAMINE Dosage & Rx Info | IMIPRAMINE Uses, Side Effects -: Indications, Side Effects, Warnings, IMIPRAMINE - Drug Information - Taj Pharma, IMIPRAMINE dose Taj pharmaceuticals IMIPRAMINE interactions, Taj Pharmaceutical IMIPRAMINE contraindications, IMIPRAMINE price, IMIPRAMINE Taj Pharma IMIPRAMINE TABLETS BP 25mg SMPC- Taj Pharma . Stay connected to all updated on IMIPRAMINE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Major Depressive Disorder is characterized by one or more episodes of depression without a history of mania. Its etiology is complex with several factors like genetics, environment, and biology contributing. Symptoms include decreased levels of neurotransmitters like serotonin and norepinephrine. Treatment involves pharmacological therapies like SSRIs, TCAs, and MAOIs to reduce symptoms as well as psychotherapy. The goals are to reduce acute symptoms, facilitate a return to normal functioning, and prevent future episodes. Treatment is conducted over acute, continuation, and maintenance phases.
Schizophrenia is a complex psychiatric disorder characterized by disorganized thoughts, delusions, hallucinations, inappropriate affect, and impaired social functioning. The exact causes are unknown but likely involve genetic, brain chemical, environmental, and family history factors. Brain imaging shows enlarged ventricles and decreased cortical size, particularly in the left temporal lobe. Symptoms include positive symptoms like hallucinations, negative symptoms like loss of interest, and mood symptoms. Treatment involves pharmacological therapy with antipsychotics and non-pharmacological approaches like therapy, social skills training, and vocational rehabilitation.
The document discusses various psychotropic medications used in psychiatry including:
1. Antipsychotics such as first-generation antipsychotics which are dopamine receptor antagonists and second-generation antipsychotics which are serotonin-dopamine antagonists or partial dopamine agonists.
2. Antidepressants which include MAOIs, TCAs, SSRIs, SNRIs, and others.
3. Mood stabilizers indicated for bipolar disorder.
4. Benzodiazepines which are commonly used as anxiolytics.
5. Anticholinergic drugs which are primarily used to treat medication-induced movement disorders.
This document discusses medication safety and the dangers posed by common household medications to children. It notes that medicines are the leading cause of child poisoning, with nearly 52,000 children under age 6 seen in emergency rooms in 2017 for medicine poisoning. Several common medications are listed that can be fatal to a 10kg child in very small doses, such as a single pill. The document also discusses lethal drug interactions and the importance of safe medication disposal to prevent accidental poisoning. It concludes that awareness of potentially fatal medications and proper disposal are needed to protect public health.
This document discusses medication safety and the dangers posed by common household medications to children. It notes that medicines are the leading cause of child poisoning, with nearly 52,000 children under age 6 seen in emergency rooms in 2017 for medicine poisoning. Several common medications are listed that can be fatal to a 10kg child in very small doses, such as a single pill. The document also covers lethal drug interactions and the importance of safe medication disposal to prevent accidental poisoning.
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Risperidone Tablets USP 0.25mg/0.5mg/1mg/2mg/3mg /4mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Risperidone Dosage & Rx Info | Risperidone Uses, Side Effects Risperidone: Indications, Side Effects, Warnings, Risperidone-Drug Information –Taj Pharma, Risperidone dose Taj pharmaceuticals Risperidone interactions, Taj Pharmaceutical Risperidone contraindications, Risperidone price, Risperidone Taj Pharma Risperidone SmPC-Taj Pharma Stay connected to all updated on Risperidone Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Mitoxantrone 2 mg per ml concentrate for solution for infusion pil, taj phar...Taj Pharma
Mitoxantrone 2 mg per ml concentrate for solution for infusion, Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Mitoxantrone Dosage & Rx Info | Mitoxantrone Uses, Side Effects – Antifungal/ Antibacterial, Mitoxantrone 2 mg per ml concentrate for solution for infusion: Indications, Side Effects, Warnings, Mitoxantrone - Drug Information - Taj Pharma, Mitoxantrone dose Taj pharmaceuticals Mitoxantrone interactions, Taj Pharmaceutical Mitoxantrone contraindications, Mitoxantrone price, Mitoxantrone , Taj Pharma Mitoxantrone 2 mg per ml concentrate for solution for infusion, - Taj Pharma . Stay connected to all updated on Mitoxantrone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
Amitriptyline 25mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Amitriptyline Dosage & Rx Info | Amitriptyline Uses, Side Effects -: Indications, Side Effects, Warnings, Amitriptyline - Drug Information - Taj Pharma, Amitriptyline dose Taj pharmaceuticals Amitriptyline interactions, Taj Pharmaceutical Amitriptyline contraindications, Amitriptyline price, Amitriptyline Taj Pharma Amitriptyline 25mg Film-Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Amitriptyline Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
This document discusses commonly used drugs in paediatric dentistry. It begins by classifying drugs into categories such as antibiotics, analgesics, local anesthetics, and drugs for conscious sedation or general anesthesia. It then provides dosing guidelines based on age, weight, or body surface area. Specific drugs are also discussed, including amoxicillin, ibuprofen, paracetamol, lidocaine and nitrous oxide. Guidelines are provided for antibiotic prophylaxis and treating paracetamol overdose. Nutritional supplements including calcium, iron and vitamins are also mentioned.
Lasmiditan is a new migraine medication that specifically targets the 5-HT 1F receptor. It was approved by the FDA in 2019 for treating migraines with or without aura in adults. Common side effects include sleepiness, dizziness and fatigue due to its action in the central nervous system. Lasmiditan is rapidly absorbed orally and primarily metabolized in the liver. Interactions can occur with other serotonin-acting drugs and alcohol. Its safety in pregnancy and breastfeeding is unknown and it is not recommended in severe hepatic impairment. When taken for moderate to severe migraines, over 1/3 of patients experienced pain relief within 2 hours.
This document provides an overview of antipsychotic drugs. It begins by defining antipsychotics as major tranquilizers or neuroleptic drugs that are primarily used to treat schizophrenia. It discusses how antipsychotics control the manifestations of psychosis but are not curative. The document then examines the types and manifestations of psychosis before focusing on the definition, symptoms, epidemiology, etiology and pathophysiology of schizophrenia. It provides details on the mechanisms of action, side effects and uses of typical and atypical antipsychotic drugs.
1. Risperidone is an antipsychotic drug approved for treating irritability in children with autism over age 5. Common side effects are weight gain and sedation. Lower doses starting at 0.25 mg are recommended.
2. Several drugs may help reduce behavioral symptoms in autistic children such as irritability, aggression, and self-injury. These include risperidone, olanzapine, aripriprazole, and lamotrigine. Careful titration and monitoring is needed due to potential side effects like weight gain.
3. Autism treatments aim to alleviate comorbid conditions, but most autistic individuals require lifelong support. While some improve, many remain
Recent advancements have been made in antidepressant drugs. Vilazodone was approved in 2011 and targets the serotonin transporter and 5-HT1A receptors. Levomilnacipran was approved in 2013 and potently inhibits the reuptake of serotonin and norepinephrine. Desipramine, a tricyclic antidepressant, is under investigation and selectively blocks the reuptake of norepinephrine while also inhibiting serotonin reuptake. Escitalopram was approved in 2002 and causes an increase in serotonin levels by preventing its reuptake. These drugs demonstrate improved mechanisms of action for the treatment of depression.
This document discusses the management of erectile dysfunction. It provides an overview of various treatment considerations including lifestyle modifications, medication changes, psychosexual therapy, hormonal therapy, pharmacologic therapy, and medical devices or surgery. Pharmacologic therapies discussed in detail include phosphodiesterase type 5 inhibitors like sildenafil, tadalafil, and avanafil. Intracavernosal injection therapies using alprostadil, papaverine, and phentolamine are also covered. The document provides guidance on optimizing effects, precautions, side effects and considerations for various erectile dysfunction treatment options.
Risperidone 2mg, 4mg Film coated Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Risperidone Dosage & Rx Info | Risperidone Uses, Side Effects - Risperidone : Indications, Side Effects, Warnings, Risperidone - Drug Information - Taj Pharma, Risperidone dose Taj pharmaceuticals Risperidone interactions, Taj Pharmaceutical Risperidone contraindications, Risperidone price, Risperidone Taj Pharma anti-psychotics Schizophrenia Risperidone 2mg, 4mg Film coated Tablets PIL- Taj Pharma . Stay connected to all updated on Risperidone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
The document discusses methamphetamine, including its potential for misuse and abuse. It can cause withdrawal symptoms in infants born to mothers dependent on amphetamines. Long term effects in children are unknown. It may exacerbate motor tics or Tourette's syndrome. Adverse reactions include increased blood pressure, psychosis, gastrointestinal issues, and changes in libido or impotence. Methamphetamine is highly addictive and abuse has led to extreme psychological dependence, social disability, and in rare cases death. Overdose can cause depressive symptoms.
Quetiapine 25mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Quetiapine Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Quetiapine Dosage & Rx Info | Quetiapine Uses, Side Effects -: Indications, Side Effects, Warnings, Quetiapine - Drug Information - Taj Pharma, Quetiapine dose Taj pharmaceuticals Quetiapine interactions, Taj Pharmaceutical Quetiapine contraindications, Quetiapine price, Quetiapine Taj Pharma Cancer, oncologyQuetiapine 25mg Film Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Quetiapine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Risperidone Dispersible Tablets Taj Pharma SmPCTajPharmaQC
Risperidone Dispersible Tablets 1mg, 2mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Risperidone Dosage & Rx Info | Risperidone Uses, Side Effects Risperidone: Indications, Side Effects, Warnings, Risperidone-Drug Information –Taj Pharma, Risperidone dose Taj pharmaceuticals Risperidone interactions, Taj Pharmaceutical Risperidone contraindications, Risperidone price, Risperidone Taj Pharma Risperidone SmPC-Taj Pharma Stay connected to all updated on Risperidone Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Demulcent is derived from the Latin word demulcēre, meaning “to soothe”
Pharyngeal Demulcents coat the pharynx and soothe the throat and reduce afferent impulses from inflammed/irritated pharyngeal mucosa, thus provide symptomatic relief in dry cough.
They include Lozenges, Syrup, Glycerine, Liquorice.
Imipramine tablets bp 25mg smpc taj pharmaceuticalsTaj Pharma
IMIPRAMINE Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, IMIPRAMINE Dosage & Rx Info | IMIPRAMINE Uses, Side Effects -: Indications, Side Effects, Warnings, IMIPRAMINE - Drug Information - Taj Pharma, IMIPRAMINE dose Taj pharmaceuticals IMIPRAMINE interactions, Taj Pharmaceutical IMIPRAMINE contraindications, IMIPRAMINE price, IMIPRAMINE Taj Pharma IMIPRAMINE TABLETS BP 25mg SMPC- Taj Pharma . Stay connected to all updated on IMIPRAMINE Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
Major Depressive Disorder is characterized by one or more episodes of depression without a history of mania. Its etiology is complex with several factors like genetics, environment, and biology contributing. Symptoms include decreased levels of neurotransmitters like serotonin and norepinephrine. Treatment involves pharmacological therapies like SSRIs, TCAs, and MAOIs to reduce symptoms as well as psychotherapy. The goals are to reduce acute symptoms, facilitate a return to normal functioning, and prevent future episodes. Treatment is conducted over acute, continuation, and maintenance phases.
Schizophrenia is a complex psychiatric disorder characterized by disorganized thoughts, delusions, hallucinations, inappropriate affect, and impaired social functioning. The exact causes are unknown but likely involve genetic, brain chemical, environmental, and family history factors. Brain imaging shows enlarged ventricles and decreased cortical size, particularly in the left temporal lobe. Symptoms include positive symptoms like hallucinations, negative symptoms like loss of interest, and mood symptoms. Treatment involves pharmacological therapy with antipsychotics and non-pharmacological approaches like therapy, social skills training, and vocational rehabilitation.
The document discusses various psychotropic medications used in psychiatry including:
1. Antipsychotics such as first-generation antipsychotics which are dopamine receptor antagonists and second-generation antipsychotics which are serotonin-dopamine antagonists or partial dopamine agonists.
2. Antidepressants which include MAOIs, TCAs, SSRIs, SNRIs, and others.
3. Mood stabilizers indicated for bipolar disorder.
4. Benzodiazepines which are commonly used as anxiolytics.
5. Anticholinergic drugs which are primarily used to treat medication-induced movement disorders.
This document discusses medication safety and the dangers posed by common household medications to children. It notes that medicines are the leading cause of child poisoning, with nearly 52,000 children under age 6 seen in emergency rooms in 2017 for medicine poisoning. Several common medications are listed that can be fatal to a 10kg child in very small doses, such as a single pill. The document also discusses lethal drug interactions and the importance of safe medication disposal to prevent accidental poisoning. It concludes that awareness of potentially fatal medications and proper disposal are needed to protect public health.
This document discusses medication safety and the dangers posed by common household medications to children. It notes that medicines are the leading cause of child poisoning, with nearly 52,000 children under age 6 seen in emergency rooms in 2017 for medicine poisoning. Several common medications are listed that can be fatal to a 10kg child in very small doses, such as a single pill. The document also covers lethal drug interactions and the importance of safe medication disposal to prevent accidental poisoning.
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Risperidone Tablets USP 0.25mg/0.5mg/1mg/2mg/3mg /4mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Risperidone Dosage & Rx Info | Risperidone Uses, Side Effects Risperidone: Indications, Side Effects, Warnings, Risperidone-Drug Information –Taj Pharma, Risperidone dose Taj pharmaceuticals Risperidone interactions, Taj Pharmaceutical Risperidone contraindications, Risperidone price, Risperidone Taj Pharma Risperidone SmPC-Taj Pharma Stay connected to all updated on Risperidone Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Mitoxantrone 2 mg per ml concentrate for solution for infusion pil, taj phar...Taj Pharma
Mitoxantrone 2 mg per ml concentrate for solution for infusion, Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Mitoxantrone Dosage & Rx Info | Mitoxantrone Uses, Side Effects – Antifungal/ Antibacterial, Mitoxantrone 2 mg per ml concentrate for solution for infusion: Indications, Side Effects, Warnings, Mitoxantrone - Drug Information - Taj Pharma, Mitoxantrone dose Taj pharmaceuticals Mitoxantrone interactions, Taj Pharmaceutical Mitoxantrone contraindications, Mitoxantrone price, Mitoxantrone , Taj Pharma Mitoxantrone 2 mg per ml concentrate for solution for infusion, - Taj Pharma . Stay connected to all updated on Mitoxantrone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
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Amitriptyline Dosage & Rx Info | Amitriptyline Uses, Side Effects -: Indications, Side Effects, Warnings, Amitriptyline - Drug Information - Taj Pharma, Amitriptyline dose Taj pharmaceuticals Amitriptyline interactions, Taj Pharmaceutical Amitriptyline contraindications, Amitriptyline price, Amitriptyline Taj Pharma Amitriptyline 25mg Film-Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Amitriptyline Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
This document discusses commonly used drugs in paediatric dentistry. It begins by classifying drugs into categories such as antibiotics, analgesics, local anesthetics, and drugs for conscious sedation or general anesthesia. It then provides dosing guidelines based on age, weight, or body surface area. Specific drugs are also discussed, including amoxicillin, ibuprofen, paracetamol, lidocaine and nitrous oxide. Guidelines are provided for antibiotic prophylaxis and treating paracetamol overdose. Nutritional supplements including calcium, iron and vitamins are also mentioned.
Lasmiditan is a new migraine medication that specifically targets the 5-HT 1F receptor. It was approved by the FDA in 2019 for treating migraines with or without aura in adults. Common side effects include sleepiness, dizziness and fatigue due to its action in the central nervous system. Lasmiditan is rapidly absorbed orally and primarily metabolized in the liver. Interactions can occur with other serotonin-acting drugs and alcohol. Its safety in pregnancy and breastfeeding is unknown and it is not recommended in severe hepatic impairment. When taken for moderate to severe migraines, over 1/3 of patients experienced pain relief within 2 hours.
This document provides an overview of antipsychotic drugs. It begins by defining antipsychotics as major tranquilizers or neuroleptic drugs that are primarily used to treat schizophrenia. It discusses how antipsychotics control the manifestations of psychosis but are not curative. The document then examines the types and manifestations of psychosis before focusing on the definition, symptoms, epidemiology, etiology and pathophysiology of schizophrenia. It provides details on the mechanisms of action, side effects and uses of typical and atypical antipsychotic drugs.
1. Risperidone is an antipsychotic drug approved for treating irritability in children with autism over age 5. Common side effects are weight gain and sedation. Lower doses starting at 0.25 mg are recommended.
2. Several drugs may help reduce behavioral symptoms in autistic children such as irritability, aggression, and self-injury. These include risperidone, olanzapine, aripriprazole, and lamotrigine. Careful titration and monitoring is needed due to potential side effects like weight gain.
3. Autism treatments aim to alleviate comorbid conditions, but most autistic individuals require lifelong support. While some improve, many remain
Recent advancements have been made in antidepressant drugs. Vilazodone was approved in 2011 and targets the serotonin transporter and 5-HT1A receptors. Levomilnacipran was approved in 2013 and potently inhibits the reuptake of serotonin and norepinephrine. Desipramine, a tricyclic antidepressant, is under investigation and selectively blocks the reuptake of norepinephrine while also inhibiting serotonin reuptake. Escitalopram was approved in 2002 and causes an increase in serotonin levels by preventing its reuptake. These drugs demonstrate improved mechanisms of action for the treatment of depression.
This document discusses the management of erectile dysfunction. It provides an overview of various treatment considerations including lifestyle modifications, medication changes, psychosexual therapy, hormonal therapy, pharmacologic therapy, and medical devices or surgery. Pharmacologic therapies discussed in detail include phosphodiesterase type 5 inhibitors like sildenafil, tadalafil, and avanafil. Intracavernosal injection therapies using alprostadil, papaverine, and phentolamine are also covered. The document provides guidance on optimizing effects, precautions, side effects and considerations for various erectile dysfunction treatment options.
Risperidone 2mg, 4mg Film coated Tablets Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Risperidone Dosage & Rx Info | Risperidone Uses, Side Effects - Risperidone : Indications, Side Effects, Warnings, Risperidone - Drug Information - Taj Pharma, Risperidone dose Taj pharmaceuticals Risperidone interactions, Taj Pharmaceutical Risperidone contraindications, Risperidone price, Risperidone Taj Pharma anti-psychotics Schizophrenia Risperidone 2mg, 4mg Film coated Tablets PIL- Taj Pharma . Stay connected to all updated on Risperidone Taj Pharmaceuticals Taj pharmaceuticals Hyderabad. Patient Information Leaflets, PIL.
The document discusses methamphetamine, including its potential for misuse and abuse. It can cause withdrawal symptoms in infants born to mothers dependent on amphetamines. Long term effects in children are unknown. It may exacerbate motor tics or Tourette's syndrome. Adverse reactions include increased blood pressure, psychosis, gastrointestinal issues, and changes in libido or impotence. Methamphetamine is highly addictive and abuse has led to extreme psychological dependence, social disability, and in rare cases death. Overdose can cause depressive symptoms.
Quetiapine 25mg film coated tablets smpc- taj pharmaceuticalsTaj Pharma
Quetiapine Taj Pharma : Uses, Side Effects, Interactions, Pictures, Warnings, Quetiapine Dosage & Rx Info | Quetiapine Uses, Side Effects -: Indications, Side Effects, Warnings, Quetiapine - Drug Information - Taj Pharma, Quetiapine dose Taj pharmaceuticals Quetiapine interactions, Taj Pharmaceutical Quetiapine contraindications, Quetiapine price, Quetiapine Taj Pharma Cancer, oncologyQuetiapine 25mg Film Coated Tablets SMPC- Taj Pharma . Stay connected to all updated on Quetiapine Taj Pharmaceuticals Taj pharmaceuticals Hyderabad.
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Risperidone Dispersible Tablets 1mg, 2mg Taj Pharma: Uses, Side Effects, Interactions, Pictures, Warnings, Risperidone Dosage & Rx Info | Risperidone Uses, Side Effects Risperidone: Indications, Side Effects, Warnings, Risperidone-Drug Information –Taj Pharma, Risperidone dose Taj pharmaceuticals Risperidone interactions, Taj Pharmaceutical Risperidone contraindications, Risperidone price, Risperidone Taj Pharma Risperidone SmPC-Taj Pharma Stay connected to all updated on Risperidone Taj Pharmaceuticals Mumbai. Patient Information Leaflets, SMPC.
Similar to 2nd-generation Antihistaminic Part I.pptx (20)
Demulcent is derived from the Latin word demulcēre, meaning “to soothe”
Pharyngeal Demulcents coat the pharynx and soothe the throat and reduce afferent impulses from inflammed/irritated pharyngeal mucosa, thus provide symptomatic relief in dry cough.
They include Lozenges, Syrup, Glycerine, Liquorice.
Antitussives also k/a cough centre suppressants, these drugs act in CNS to raise the threshold of cough centre or act peripherally in the respiratory tract to reduce tussal impulses.
Antitussives should be used only for dry nonproductive cough, or if it is unduly tiring, disturbs sleep or is hazardous (rib fracture, hernia, piles, cardiac disease, ocular surgery).
First and only Histaminergic treatment for Excessive Daytime Sleepiness in adult patients with Narcolepsy
Pitolisant comes under the brand name ‘Wakix’
Approved on 15th August,2019
Daxibotulinumtoxin A-lanm comes under the brand name Daxxify.
First and Only Peptide-Formulated Neuromodulator with long lasting results.
Approved by US- FDA on 7th September 2022
Solriamfetol-Dopamine and Norepinephrine Reuptake Inhibitor .pptxMadhumita Dixit
Solriamfetol sold under brand name “Sunosi”
It is a Dopamine and Norepinephrine Reuptake Inhibitor (DNRI) indicated to improve wakefulness in adult patients with excessive daytime sleepiness associated with narcolepsy or Obstructive Sleep Apnea (OSA).
Date of Approval: March 20, 2019
Preferential and selective COX-2 inhibitors.pptxMadhumita Dixit
Cyclo-oxygenase inhibitors -These drugs have three major therapeutic actions
1)Anti-inflammatory action: The decrease in prostaglandin E2 and prostacyclin reduces vasodilatation and, indirectly, oedema. Accumulation of inflammatory cells is not directly reduced.
2) Analgesic effect: Decreased prostaglandin generation means less sensitization of nociceptive nerve endings to inflammatory mediators such as Bradykinin and 5-hydroxytryptamine. Relief of headache is probably a result of decreased prostaglandin-mediated vasodilatation.
3) Antipyretic effect: Interleukin-1 releases prostaglandins in the central nervous system, where they elevate the hypothalamic set point for temperature control, thus causing fever, NSAIDs prevent this.
Fexofenadine is sold under the brand name Allegra.
It is a selective peripheral H1 blocker. It is classified as a second-generation antihistamine because it is less able to pass the blood–brain barrier and causes lesser sedation, as compared to first-generation antihistamines.
It is on the World Health Organization's List of Essential Medicines. Fexofenadine has been manufactured in generic form since 2011.
It is an alkaloid obtained from the plant Colchicum Autumnale.
It is neither analgesic, nor anti-inflammatory, but specifically suppresses gouty inflammation.
It was first described for treatment of rheumatism
and swelling in the Ebers Papyrus(Egyptian medical text) in 1500 BC.
Allopurinol, a uric acid synthesis inhibitor acts by inhibiting Xanthine oxidase competitively as well as non- competitively, Whereas Oxypurinol is a non-competitive inhibitor of xanthine oxidase.
Selective alpha1 blockers are Prazosin, Terazosin, Doxazosin, Tamsulosin and Silodosin majorly used to treat BPH, also hypertension, PTSD, Raynaud's phenomenon, CHF
A congenital heart defect is a problem with the structure of the heart that a child is born with.
Some congenital heart defects in children are simple and don't need treatment. Others are more complex. The child may need several surgeries done over a period of several years.
PGx Analysis in VarSeq: A User’s PerspectiveGolden Helix
Since our release of the PGx capabilities in VarSeq, we’ve had a few months to gather some insights from various use cases. Some users approach PGx workflows by means of array genotyping or what seems to be a growing trend of adding the star allele calling to the existing NGS pipeline for whole genome data. Luckily, both approaches are supported with the VarSeq software platform. The genotyping method being used will also dictate what the scope of the tertiary analysis will be. For example, are your PGx reports a standalone pipeline or would your lab’s goal be to handle a dual-purpose workflow and report on PGx + Diagnostic findings.
The purpose of this webcast is to:
Discuss and demonstrate the approaches with array and NGS genotyping methods for star allele calling to prep for downstream analysis.
Following genotyping, explore alternative tertiary workflow concepts in VarSeq to handle PGx reporting.
Moreover, we will include insights users will need to consider when validating their PGx workflow for all possible star alleles and options you have for automating your PGx analysis for large number of samples. Please join us for a session dedicated to the application of star allele genotyping and subsequent PGx workflows in our VarSeq software.
This presentation gives information on the pharmacology of Prostaglandins, Thromboxanes and Leukotrienes i.e. Eicosanoids. Eicosanoids are signaling molecules derived from polyunsaturated fatty acids like arachidonic acid. They are involved in complex control over inflammation, immunity, and the central nervous system. Eicosanoids are synthesized through the enzymatic oxidation of fatty acids by cyclooxygenase and lipoxygenase enzymes. They have short half-lives and act locally through autocrine and paracrine signaling.
The Children are very vulnerable to get affected with respiratory disease.
In our country, the respiratory Disease conditions are consider as major cause for mortality and Morbidity in Child.
Discover the benefits of homeopathic medicine for irregular periods with our guide on 5 common remedies. Learn how these natural treatments can help regulate menstrual cycles and improve overall menstrual health.
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Nutritional deficiency Disorder are problems in india.
It is very important to learn about Indian child's nutritional parameters as well the Disease related to alteration in their Nutrition.
2. CLASSIFICATION OF H1 ANTIHISTAMINICS-
FIRST GENERATION ANTIHISTAMINICS-
1)HIGHLY SEDATIVE-DIPHENHYDRAMINE,DIMENHYDRINATE,
PROMETHAZINE,HYDROXYZINE
2)MODERATELY SEDATIVE-PHENARIMINE,CYPROHEPTADINE,
MECLIZINE,CINNARIZINE
3)MILD SEDATIVE-CHLORPHENIRAMINE,DEXCHLORPHENIRAMINE
TRIPROLIDINE,CLEMASTINE
SECOND GENERATION ANTIHISTAMINICS-FEXOFENADINE,
LORATADINE,DESLORATADINE,CETIRIZINE,LEVOCETIRIZINE,
AZELASTINE,MIZOLASTINE,EBASTINE,RUPATADINE
3. Mechanism of action of 2nd generation antihistaminics-
These drugs competitively antagonize actions of
histamine at the H1 receptors.
Pharmacological actions-
1) Antagonism of histamine-The H1 antagonists
effectively block histamine induced
bronchoconstriction, contraction of intestinal and
other smooth muscle and triple response especially
wheal, flare and itch. Constriction of larger blood
vessel by histamine is also antagonized.
2) Antiallergic actions-Many manifestations
of immediate hypersensitivity (type I reactions)
are suppressed. Urticaria, itching and angioedema
are well controlled.
4. 3) CNS action-The older antihistamines produce
variable degree of CNS depression.But in case of 2nd
gen antihistaminics there is less CNS depressant
property as these cross BBB to significantly lesser
extent.
4) Anticholinergic action- many H1 blockers
in addition antagonize muscarinic actions of ACh.
BUT IN 2ND gen histaminics there is Higher H1
selectivitiy : no anticholinergic side effects
5. •Cetirizine, sold under the brand
name Zyrtec among others, is a second-
generation antihistamine
•It was patented in 1981and came into medical
use in 1987. It is available as a generic
medication.It is on the World Health
Organization's List of Essential Medicines.
6. USES-
1 . Allergic disorders –cetirizine do not suppress AG:
AB reaction, but block the Effects of released
histamine. Cetirizine's primary indication is
for allergic rhinitis(hay fever),dermatitis and other
allergies. Because the symptoms of itching and
redness in these conditions are caused by histamine
acting on the H1 receptor, blocking those receptors
temporarily relieves those symptoms.
Cetirizine is also commonly prescribed to treat acute
and chronic urticaria(hives)
7. Route of administration-Cetirizine comes as a tablet, a
chewable tablet, an extended release tablet, and a
syrup (liquid) to taken orally. It is taken once a day with
or without food usually before bedtime.
Pharmacokinetics-
Bioavailability-Well-absorbed (>70%)
Protein binding-88–96%
Metabolism Minimal (non-cytochrome P450 mediated)
Onset of action-20–42 minutes
Elimination half-life Mean: 8.3 hours Range: 6.5–10
hours
Duration of action≥24 hours
Excretion-
Urine: 70–85%
Feces: 10–13%
8. Dosing-The dosing of cetirizine depends on patient age. In
adults and children 12 years or older, the recommended dose is
5 or 10 mg per day orally, depending on symptom severity. It is
available in 5 mg and 10 mg tablets and 5 mg/ 5 ml oral
solution
•In children 6 to 11 years old, 5 or 10 mg (1 or 2 teaspoons)
once daily in syrup form is recommended depending on
symptom severity.
•In children 2 to 5 years old, the recommended dose is 2.5 mg
(half teaspoon) in syrup form once daily.
•In children six months to 23 months old, the recommended
dose is 2.5 mg (half teaspoon) in syrup form once daily.
•One drop (0.24% cetirizine hydrochloride ophthalmic solution) is
instilled in the affected eye twice daily for patients with allergic
conjunctivitis.
9. •Abuse potential-Antihistamines are easily accessible
medications, usually sold OTC to treat allergic
reactions, pruritus, or peripheral vertigo. Their
sedating effects have led to usage as a sleep aid or an
anxiolytic, often by child and adolescent mental health
practitioners, particularly in acute inpatient psychiatric
hospital settings.
• Although widely used and generally considered safe,
cases of antihistamine abuse and dependence,
especially of DPH, have been described in the medical
literatures.
12. Interactions-
Isocarboxazid -cetirizine interaction-
Using cetirizine together with isocarboxazid may increase side effects
such as dizziness, drowsiness, and difficulty concentrating. Some people,
especially the elderly, may also experience impairment in thinking,
judgment, and motor coordination.
Tranylcypromine -cetirizine interaction-
Using cetirizine together with tranylcypromine may increase side effects
such as dizziness, drowsiness, and difficulty concentrating.
cetirizine -alcohol interaction-
Alcohol can increase the nervous system side effects of cetirizine such as
dizziness, drowsiness, and difficulty concentrating. Some people may also
experience impairment in thinking and judgment. You should avoid or
limit the use of alcohol while being treated with cetirizine. Do not use
more than the recommended dose of cetirizine, and avoid activities
requiring mental alertness such as driving or operating hazardous
machinery.
13. Also avoid use of sedatives, and tranquilizers as cetirizine can
increase the risk of drowsiness. Cetirizine may cause central
nervous system depression; avoid activities requiring mental
alertness until accustomed to the medication.
First-generation antihistamines are considered safe to use during
pregnancy. There are relatively fewer data on the nonsedating
second-generation antihistamines; however, published studies are
reassuring. All antihistamines are considered safe to use during
breastfeeding, as minimal amounts are excreted in the breast milk
and would not cause any adverse effects on a breastfeeding infant.
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