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ACTA SCIENTIFIC MEDICAL SCIENCES
Patient Perception from Internet on Adverse Effects vs Benefits of Vaccination -
An Internet Message from a Public Figure in Hong Kong
Cecilia Young* and TH Tai
Independent Researcher, Kowloon, Hong Kong
*Corresponding Author: Cecilia Young, Independent Researcher, Kowloon, Hong Kong.
Short Communication
Received: March 07, 2018; Published: April 30, 2018
Volume 2 Issue 2 May 2018
Influenza viruses are important human respiratory pathogens
that can cause seasonal influenza epidemics and out-of-season
sporadic cases and outbreaks. Influenza occurs globally with an
annual attack rate estimated at 5%-10% in adults and 20%-30%
in children [1]. Yet, a message on Internet during winter peak of
2018 influenza has provoked widespread discussion in Hong Kong
regarding vaccination [2,3].
Introduction
Internet exposure can significantly affect patient perception of
vaccination. Viewing typical vaccine-critical websites for only 5-10
minutes increases the perception of risk regarding vaccinations
and decreases the perception of risk regarding the omission of vac-
cinations as compared to visiting a control site [13].
The voice message on internet raised several questions regard-
ing influenza vaccination [4]:
Content of the Internet voice message
The exposure to information including from Internet may be
associated with negative effect on public’s perception towards
healthcare programmes, such as vaccination. General public ob-
jects to vaccination due to fear of adverse effect, perception of in-
sufficient test, ‘public panicking’, necessity, and lack of information
of vaccine [14].
From February 07, 2018 [2,3], a 5-minute voice message has ap-
peared on Internet forum. It is released by a Hong Kong celebrity
in private discussion and uploaded by other people on a parents’
forum which then spread through Internet, in which the content
mainly focuses on the harmful ingredients like mercury and alumi-
num, bacteria existence may cause iatrogenic disease, mutation of
bacteria due to human and animal DNA mixing, high risk and low
effectiveness of vaccination [4].
Widespread of the message through Internet led to intense
public discussion regarding the issue, and various healthcare pro-
fessionals have responded to the event in announcement [5] and
news [6-11], including government official [5], legislator [6,7], and
professor [8-11]. The vigorous debate among various groups trans-
formed the issue into an event of societal level.
1.	 The vaccine contains mercury and aluminum as part of the
composition
2.	 Scientists “gamble” about the type of influenza virus by
chance
3.	 The vaccine is produced by injecting bacteria into chicken’s
body and then the eggs contain the bacteria, such mixture of
human and animal DNA cause mutation
4.	 The bacteria become “super-bacteria” after the injection
into human body and cause iatrogenic illness of a healthy
person.
These claims have raised vigorous public concern and discus-
sion, which may lead to discouragement of vaccination by the pub-
lic.
A group of medical professionals responded quickly after the
spread of voice message on Internet.
Response from various medical professionals
A group of medical professionals stated on Internet that all
Hong Kong independently packaged single-dose seasonal influenza
vaccines does not contain thimerosal [12].
Composition
A statement from the Department of Health claimed that this
season’s vaccine strains closely match the influenza viruses that are
circulating this winter influenza season in Hong Kong [5].
Effectiveness of vaccine
A news article mentioning the opinion of Professor YUEN of the
University of Hong Kong state that the vaccine is injected to the egg
and the production is based on the embryo of chicken. The virus is
then killed and followed by isolation and purification of antigens.
Thus most of the vaccines are purified. The amount of remaining
egg white is negligible and is harmless [10,11].
The animal-based vaccine would not cause adverse events to
host
Patients’ perception is strongly affected by Internet informa-
tion
Mistrust towards the authorities (government, public health
professionals) also plays a role in vaccine hesitancy, as parents
who did not fully vaccinate their children held feelings of distrust
towards government [15].
Citation: Cecilia Young and TH Tai. “Patient Perception from Internet on Adverse Effects vs Benefits of Vaccination - An Internet Message from a Public
Figure in Hong Kong”. Acta Scientific Medical Sciences 2.2 (2018) 45-47.
Patient Perception from Internet on Adverse Effects vs Benefits of Vaccination - An Internet Message from a Public Figure in Hong Kong
Vaccination perception is negatively affected by exposure to In-
ternet information, as parents and general public tend to be nega-
tively influenced by Internet opinion regarding vaccination safety,
and current initiatives aiming to reach and influence parents’ deci-
sion to vaccinate have not adequately abated the influence of the
online anti-vaccination movement [16].
Health education and promotion about vaccination
Individual level
Parents’ decision regarding vaccination mainly depends on phy-
sician recommendation, effectiveness and risk of temporary side
effects (presence of mercury-containing preservative) [17]. Diffu-
sion of negative information online and lack of knowledge about
vaccines were identified as the key causes of vaccine hesitancy
[18]. A study suggested that for individual-based health education,
a medical consultation regarding information about influenza vac-
cination and a clear recommendation by the presenting physician
is a strong factor on accepting vaccination [19].
At the primary care practitioner level, parental education on
influenza vaccine regarding efficacy and safety may also help to
improve pediatric vaccination rates. General public often weighs
vaccine effectiveness heavily [17], and physicians should provide
sufficient information to general public before making decision on
vaccination. For example, physicians should state there are varying
effectiveness of vaccinations season in various countries, and effec-
tiveness of vaccine against influenza A and B in 2017-2018 season
is reported to be 36% in US [20].
Medical professionals should well-educate public regarding the
use of preservatives in vaccine. Physicians may inform general pub-
lic the existence of thimerosal, and that it is very unlikely to cause
adverse outcomes [21]. Also, the peak body mercury burdens af-
ter exposure to thimerosal-containing vaccines did not exceed the
maximum burden of mercury even in underweight infants [22].
Physicians may also educate general public on egg allergy in
view of vaccine hesitancy. Before vaccination, relevant medical his-
tory of allergy should be well-obtained, and potential allergic risk
should be well-explained. Egg-related severe allergic reaction is
extremely rare, as anaphylaxis after vaccination is rare in all age
groups [23]. A study stated that egg-based trivalent influenza vac-
cine can be safely administered even in children with severe egg
allergy [24].
Community based
The event provides a good example for the tremendous effect
of mass media, such as Internet, on general public perception and
hence affect population health in terms of healthcare coverage.
As general public opinion on Internet may produce great effect
on public perception towards vaccination, there might be a need
of public health intervention through effective ways using Internet
and online resources [16].
General public, especially adolescents, does not show enough
sophistication of appraisal skills to correctly judge on information
from Internet sources, and some even does not search on Internet
to verify information. Public tends to be affected by first-impres-
sion of information on Internet [25], tends to judge information
based on instinctive response [25], as well as tends to believe in
majority of websites if in doubt, instead of critically appraising the
material [26]. Mcpherson., et al. also stated that many people re-
quire greater skills for assessing the quality and trustworthiness
of online health information [26].
It is thus encouraged for the public to learn to verify Internet
information through database search in order to acquire better
searching and critical appraisal skills, as the establishment of ac-
curate and authoritative online healthcare database may enhance
general public medical knowledge [27]. It is also suggested that
healthcare professionals should consider to promote population
health programmes through Internet. Parents nowadays are more
affected by information from Web sites and electronic means of
communication [28].
Conclusion
The event is thus a good reminder for authorities, including
government and medical professionals, to notice the importance
and powerfulness of Internet information spread among general
public, which may have tremendous effect on public perception
and decision-making regarding healthcare programmes includ-
ing seasonal influenza vaccination. We suggest there is a need to
strengthen public health education through Internet materials, as
well as guidance to appraise information, and the education mate-
rial should focus on vaccine effectiveness and clarifying the misun-
derstandings of vaccination.
Bibliography
1.	 “Weekly epidemiological record. 23 November 2012, 87th
year”. World Health Organization 47.87 (2012): 461-476.
2.	 Yuen LT and Li SW. “Recording suspected to be from Kay
Tse- vaccination will cause infection.” (2018).
3.	 Yuen LT. “Recording suspected to be from celebrity Kay
Tse-Receiving influenza vaccine will get sick” (2018).
4.	 H2
O Steam Water Ice Forum. “Recording comment on influ-
enza from celebrity Kay Tse.” (2018).
5.	 YU. “DH reiterates that influenza vaccination is safe and ef-
fective”. Department of Health (2018).
6.	 Sing Tao Daily. “Vaccination is useless? Chan Pui Yin point-
to-point “fact check”, states unverified information is
harmful.” (2018).
7.	 H2
O Steam Water Ice Forum. “Is vaccination useless? Chan
Pui Yin refutes every point by “fact check”, who blames
the release of unreliable messages could be lethal- Yahoo
News”. (2018).
Citation: Cecilia Young and TH Tai. “Patient Perception from Internet on Adverse Effects vs Benefits of Vaccination - An Internet Message from a Public
Figure in Hong Kong”. Acta Scientific Medical Sciences 2.2 (2018) 45-47.
46
Patient Perception from Internet on Adverse Effects vs Benefits of Vaccination - An Internet Message from a Public Figure in Hong Kong
Volume 2 Issue 2 May 2018
© All rights are reserved by Cecilia Young and TH Tai.
8.	 Rumors of bacteria and mercury in seasonal influenza vac-
cine- Yuen Kwok-yung rebuts Kay Tse (2018).
9.	 H2
O Steam Water Ice Forum. “Rumor about the presence of
bacteria and mercury in seasonal influenza vaccine -Yuen
Kwok-yung rebuts the speech from Kay Tse.” (2018).
10.	 Hong Kong Economic Times. “Crazy spread of the “anti-vac-
cine” recording from Kay Tse; Yuen Kwok-yung : completely
wrong.” (2018).
11.	 H2
O Steam Water Ice Forum. “Crazy spread of the “anti-
vaccination” recording from Kay Tse Yuen Kwok-yung: This
is completely wrong- Hong Kong Economic Times.” (2018).
12.	 Médecins Inspirés. Declaration. (2018).
13.	 Cornelia Betsch, et al. “The influence of vaccine-critical
websites on perceiving vaccination risks”. Journal of Health
Psychology 15.3 (2010): 446-455.
14.	 Walter D., et al. “Risk perception and information-seeking
behaviour during the 2009/10 influenza A(H1N1)pdm09
pandemic in Germany”. Euro Surveillance 17.13 (2012):
20131.
15.	 Wilson K., et al. “Parental views on pediatric vaccination:
the impact of competing advocacy coalitions”. Public Under-
standing of Science 17.2 (2008): 231-243.
16.	 Tustin JL., et al. “Internet Exposure Associated With Canadi-
an Parents’ Perception of Risk on Childhood Immunization:
Cross-Sectional Study”. JMIR Public Health and Surveillance
4.1 (2018): e7.
17.	 Emuella M Flood., et al. “Parent preferences for pediatric in-
fluenza vaccine attributes”. Clinical Pediatrics 50.4 (2011):
338-347.
18.	 Dubé E., et al. “Understanding Vaccine Hesitancy in Canada:
Results of a Consultation Study by the Canadian Immuniza-
tion Research Network”. PLoS ONE 11.6 (2016): e0156118.
19.	 Wolfgang Poeppl., et al. “Influenza vaccination perception
and coverage among patients with malignant disease”. Vac-
cine 33.14 (2015): 1682-1687.
20.	 Budd AP., et al. “Update: Influenza Activity - United States,
October 1, 2017-February 3, 2018”. MMWR Morbidity and
Mortality Weekly Report 67.6 (2018): 169-179.
21.	 William W Thompson, et al. “Early thimerosal exposure and
neuropsychological outcomes at 7 to 10 years”. New Eng-
land Journal of Medicine 357.13 (2007): 1281-1292.
22.	 RJ Mitkus., et al. “A comparative pharmacokinetic estimate
of mercury in U.S. Infants following yearly exposures to
inactivated influenza vaccines containing thimerosal”. Risk
Analysis 34.4 (2014): 735-750.
23.	 McNeil MM., et al. “Risk of anaphylaxis after vaccination in
children and adults”. The Journal of Allergy and Clinical Im-
munology 137.3 (2016): 868-878.
24.	 Matthew J Greenhawt., et al. “Safe administration of the sea-
sonal trivalent influenza vaccine to children with severe egg
allergy”. Annals of Allergy, Asthma and Immunology 109.6
(2012): 426-430.
25.	 Jaimie L Freeman., et al. “How Adolescents Search for and
Appraise Online Health Information: A Systematic Review”.
The Journal of Pediatrics (2018).
26.	 McPherson AC., et al. “Seeing is believing? A mixed meth-
ods study exploring the quality and perceived trustworthi-
ness of online information about chronic conditions aimed
at children and young people”. Health Communication 29.5
(2014): 473-482.
27.	 Freund O., et al. “The ability of older adults to use custom-
ized online medical databases to improve their health-
related knowledge”. International Journal of Medical Infor-
matics 102 (2017): 1-11.
28.	 Freed GL., et al. “Sources and perceived credibility of
vaccine-safety information for parents”. Pediatrics 127.1
(2011): S107-S112.
Citation: Cecilia Young and TH Tai. “Patient Perception from Internet on Adverse Effects vs Benefits of Vaccination - An Internet Message from a Public
Figure in Hong Kong”. Acta Scientific Medical Sciences 2.2 (2018) 45-47.
47

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醫藥人 楊幽幽 Physician Pharmacist People Health Magazine Cecilia Young Tau Yau - Patient Perception from Internet on Adverse Effects vs Benefits of Vaccination

  • 1. ACTA SCIENTIFIC MEDICAL SCIENCES Patient Perception from Internet on Adverse Effects vs Benefits of Vaccination - An Internet Message from a Public Figure in Hong Kong Cecilia Young* and TH Tai Independent Researcher, Kowloon, Hong Kong *Corresponding Author: Cecilia Young, Independent Researcher, Kowloon, Hong Kong. Short Communication Received: March 07, 2018; Published: April 30, 2018 Volume 2 Issue 2 May 2018 Influenza viruses are important human respiratory pathogens that can cause seasonal influenza epidemics and out-of-season sporadic cases and outbreaks. Influenza occurs globally with an annual attack rate estimated at 5%-10% in adults and 20%-30% in children [1]. Yet, a message on Internet during winter peak of 2018 influenza has provoked widespread discussion in Hong Kong regarding vaccination [2,3]. Introduction Internet exposure can significantly affect patient perception of vaccination. Viewing typical vaccine-critical websites for only 5-10 minutes increases the perception of risk regarding vaccinations and decreases the perception of risk regarding the omission of vac- cinations as compared to visiting a control site [13]. The voice message on internet raised several questions regard- ing influenza vaccination [4]: Content of the Internet voice message The exposure to information including from Internet may be associated with negative effect on public’s perception towards healthcare programmes, such as vaccination. General public ob- jects to vaccination due to fear of adverse effect, perception of in- sufficient test, ‘public panicking’, necessity, and lack of information of vaccine [14]. From February 07, 2018 [2,3], a 5-minute voice message has ap- peared on Internet forum. It is released by a Hong Kong celebrity in private discussion and uploaded by other people on a parents’ forum which then spread through Internet, in which the content mainly focuses on the harmful ingredients like mercury and alumi- num, bacteria existence may cause iatrogenic disease, mutation of bacteria due to human and animal DNA mixing, high risk and low effectiveness of vaccination [4]. Widespread of the message through Internet led to intense public discussion regarding the issue, and various healthcare pro- fessionals have responded to the event in announcement [5] and news [6-11], including government official [5], legislator [6,7], and professor [8-11]. The vigorous debate among various groups trans- formed the issue into an event of societal level. 1. The vaccine contains mercury and aluminum as part of the composition 2. Scientists “gamble” about the type of influenza virus by chance 3. The vaccine is produced by injecting bacteria into chicken’s body and then the eggs contain the bacteria, such mixture of human and animal DNA cause mutation 4. The bacteria become “super-bacteria” after the injection into human body and cause iatrogenic illness of a healthy person. These claims have raised vigorous public concern and discus- sion, which may lead to discouragement of vaccination by the pub- lic. A group of medical professionals responded quickly after the spread of voice message on Internet. Response from various medical professionals A group of medical professionals stated on Internet that all Hong Kong independently packaged single-dose seasonal influenza vaccines does not contain thimerosal [12]. Composition A statement from the Department of Health claimed that this season’s vaccine strains closely match the influenza viruses that are circulating this winter influenza season in Hong Kong [5]. Effectiveness of vaccine A news article mentioning the opinion of Professor YUEN of the University of Hong Kong state that the vaccine is injected to the egg and the production is based on the embryo of chicken. The virus is then killed and followed by isolation and purification of antigens. Thus most of the vaccines are purified. The amount of remaining egg white is negligible and is harmless [10,11]. The animal-based vaccine would not cause adverse events to host Patients’ perception is strongly affected by Internet informa- tion Mistrust towards the authorities (government, public health professionals) also plays a role in vaccine hesitancy, as parents who did not fully vaccinate their children held feelings of distrust towards government [15]. Citation: Cecilia Young and TH Tai. “Patient Perception from Internet on Adverse Effects vs Benefits of Vaccination - An Internet Message from a Public Figure in Hong Kong”. Acta Scientific Medical Sciences 2.2 (2018) 45-47.
  • 2. Patient Perception from Internet on Adverse Effects vs Benefits of Vaccination - An Internet Message from a Public Figure in Hong Kong Vaccination perception is negatively affected by exposure to In- ternet information, as parents and general public tend to be nega- tively influenced by Internet opinion regarding vaccination safety, and current initiatives aiming to reach and influence parents’ deci- sion to vaccinate have not adequately abated the influence of the online anti-vaccination movement [16]. Health education and promotion about vaccination Individual level Parents’ decision regarding vaccination mainly depends on phy- sician recommendation, effectiveness and risk of temporary side effects (presence of mercury-containing preservative) [17]. Diffu- sion of negative information online and lack of knowledge about vaccines were identified as the key causes of vaccine hesitancy [18]. A study suggested that for individual-based health education, a medical consultation regarding information about influenza vac- cination and a clear recommendation by the presenting physician is a strong factor on accepting vaccination [19]. At the primary care practitioner level, parental education on influenza vaccine regarding efficacy and safety may also help to improve pediatric vaccination rates. General public often weighs vaccine effectiveness heavily [17], and physicians should provide sufficient information to general public before making decision on vaccination. For example, physicians should state there are varying effectiveness of vaccinations season in various countries, and effec- tiveness of vaccine against influenza A and B in 2017-2018 season is reported to be 36% in US [20]. Medical professionals should well-educate public regarding the use of preservatives in vaccine. Physicians may inform general pub- lic the existence of thimerosal, and that it is very unlikely to cause adverse outcomes [21]. Also, the peak body mercury burdens af- ter exposure to thimerosal-containing vaccines did not exceed the maximum burden of mercury even in underweight infants [22]. Physicians may also educate general public on egg allergy in view of vaccine hesitancy. Before vaccination, relevant medical his- tory of allergy should be well-obtained, and potential allergic risk should be well-explained. Egg-related severe allergic reaction is extremely rare, as anaphylaxis after vaccination is rare in all age groups [23]. A study stated that egg-based trivalent influenza vac- cine can be safely administered even in children with severe egg allergy [24]. Community based The event provides a good example for the tremendous effect of mass media, such as Internet, on general public perception and hence affect population health in terms of healthcare coverage. As general public opinion on Internet may produce great effect on public perception towards vaccination, there might be a need of public health intervention through effective ways using Internet and online resources [16]. General public, especially adolescents, does not show enough sophistication of appraisal skills to correctly judge on information from Internet sources, and some even does not search on Internet to verify information. Public tends to be affected by first-impres- sion of information on Internet [25], tends to judge information based on instinctive response [25], as well as tends to believe in majority of websites if in doubt, instead of critically appraising the material [26]. Mcpherson., et al. also stated that many people re- quire greater skills for assessing the quality and trustworthiness of online health information [26]. It is thus encouraged for the public to learn to verify Internet information through database search in order to acquire better searching and critical appraisal skills, as the establishment of ac- curate and authoritative online healthcare database may enhance general public medical knowledge [27]. It is also suggested that healthcare professionals should consider to promote population health programmes through Internet. Parents nowadays are more affected by information from Web sites and electronic means of communication [28]. Conclusion The event is thus a good reminder for authorities, including government and medical professionals, to notice the importance and powerfulness of Internet information spread among general public, which may have tremendous effect on public perception and decision-making regarding healthcare programmes includ- ing seasonal influenza vaccination. We suggest there is a need to strengthen public health education through Internet materials, as well as guidance to appraise information, and the education mate- rial should focus on vaccine effectiveness and clarifying the misun- derstandings of vaccination. Bibliography 1. “Weekly epidemiological record. 23 November 2012, 87th year”. World Health Organization 47.87 (2012): 461-476. 2. Yuen LT and Li SW. “Recording suspected to be from Kay Tse- vaccination will cause infection.” (2018). 3. Yuen LT. “Recording suspected to be from celebrity Kay Tse-Receiving influenza vaccine will get sick” (2018). 4. H2 O Steam Water Ice Forum. “Recording comment on influ- enza from celebrity Kay Tse.” (2018). 5. YU. “DH reiterates that influenza vaccination is safe and ef- fective”. Department of Health (2018). 6. Sing Tao Daily. “Vaccination is useless? Chan Pui Yin point- to-point “fact check”, states unverified information is harmful.” (2018). 7. H2 O Steam Water Ice Forum. “Is vaccination useless? Chan Pui Yin refutes every point by “fact check”, who blames the release of unreliable messages could be lethal- Yahoo News”. (2018). Citation: Cecilia Young and TH Tai. “Patient Perception from Internet on Adverse Effects vs Benefits of Vaccination - An Internet Message from a Public Figure in Hong Kong”. Acta Scientific Medical Sciences 2.2 (2018) 45-47. 46
  • 3. Patient Perception from Internet on Adverse Effects vs Benefits of Vaccination - An Internet Message from a Public Figure in Hong Kong Volume 2 Issue 2 May 2018 © All rights are reserved by Cecilia Young and TH Tai. 8. Rumors of bacteria and mercury in seasonal influenza vac- cine- Yuen Kwok-yung rebuts Kay Tse (2018). 9. H2 O Steam Water Ice Forum. “Rumor about the presence of bacteria and mercury in seasonal influenza vaccine -Yuen Kwok-yung rebuts the speech from Kay Tse.” (2018). 10. Hong Kong Economic Times. “Crazy spread of the “anti-vac- cine” recording from Kay Tse; Yuen Kwok-yung : completely wrong.” (2018). 11. H2 O Steam Water Ice Forum. “Crazy spread of the “anti- vaccination” recording from Kay Tse Yuen Kwok-yung: This is completely wrong- Hong Kong Economic Times.” (2018). 12. Médecins Inspirés. Declaration. (2018). 13. Cornelia Betsch, et al. “The influence of vaccine-critical websites on perceiving vaccination risks”. Journal of Health Psychology 15.3 (2010): 446-455. 14. Walter D., et al. “Risk perception and information-seeking behaviour during the 2009/10 influenza A(H1N1)pdm09 pandemic in Germany”. Euro Surveillance 17.13 (2012): 20131. 15. Wilson K., et al. “Parental views on pediatric vaccination: the impact of competing advocacy coalitions”. Public Under- standing of Science 17.2 (2008): 231-243. 16. Tustin JL., et al. “Internet Exposure Associated With Canadi- an Parents’ Perception of Risk on Childhood Immunization: Cross-Sectional Study”. JMIR Public Health and Surveillance 4.1 (2018): e7. 17. Emuella M Flood., et al. “Parent preferences for pediatric in- fluenza vaccine attributes”. Clinical Pediatrics 50.4 (2011): 338-347. 18. Dubé E., et al. “Understanding Vaccine Hesitancy in Canada: Results of a Consultation Study by the Canadian Immuniza- tion Research Network”. PLoS ONE 11.6 (2016): e0156118. 19. Wolfgang Poeppl., et al. “Influenza vaccination perception and coverage among patients with malignant disease”. Vac- cine 33.14 (2015): 1682-1687. 20. Budd AP., et al. “Update: Influenza Activity - United States, October 1, 2017-February 3, 2018”. MMWR Morbidity and Mortality Weekly Report 67.6 (2018): 169-179. 21. William W Thompson, et al. “Early thimerosal exposure and neuropsychological outcomes at 7 to 10 years”. New Eng- land Journal of Medicine 357.13 (2007): 1281-1292. 22. RJ Mitkus., et al. “A comparative pharmacokinetic estimate of mercury in U.S. Infants following yearly exposures to inactivated influenza vaccines containing thimerosal”. Risk Analysis 34.4 (2014): 735-750. 23. McNeil MM., et al. “Risk of anaphylaxis after vaccination in children and adults”. The Journal of Allergy and Clinical Im- munology 137.3 (2016): 868-878. 24. Matthew J Greenhawt., et al. “Safe administration of the sea- sonal trivalent influenza vaccine to children with severe egg allergy”. Annals of Allergy, Asthma and Immunology 109.6 (2012): 426-430. 25. Jaimie L Freeman., et al. “How Adolescents Search for and Appraise Online Health Information: A Systematic Review”. The Journal of Pediatrics (2018). 26. McPherson AC., et al. “Seeing is believing? A mixed meth- ods study exploring the quality and perceived trustworthi- ness of online information about chronic conditions aimed at children and young people”. Health Communication 29.5 (2014): 473-482. 27. Freund O., et al. “The ability of older adults to use custom- ized online medical databases to improve their health- related knowledge”. International Journal of Medical Infor- matics 102 (2017): 1-11. 28. Freed GL., et al. “Sources and perceived credibility of vaccine-safety information for parents”. Pediatrics 127.1 (2011): S107-S112. Citation: Cecilia Young and TH Tai. “Patient Perception from Internet on Adverse Effects vs Benefits of Vaccination - An Internet Message from a Public Figure in Hong Kong”. Acta Scientific Medical Sciences 2.2 (2018) 45-47. 47
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