This document discusses emerging viruses that pose risks as contaminants in raw materials used to manufacture vaccines and biological products. It outlines various risk mitigation strategies, including risk assessments of potential contaminating viruses to inform detection methods. Specific viruses that are addressed include porcine circovirus type 3, hepatitis E virus, Schmallenberg virus, Zika virus, and Borna disease virus. Next-generation sequencing is presented as an advantageous method for the holistic screening of raw materials to identify both known and novel viruses. Quality by design approaches are emphasized to continuously reassess risks from emerging viruses.