A study on the V-shaped microstrip patch antenna for multiple-input multiple-output (MIMO) communication system based on the antenna orientation is performed. First the microstrip patch antenna operating at 2.45 GHz is calculated and simulated. Next, multiple elements of antennas for MIMO system is simulated and discussed. V-shaped with 45 degree slanted inward and outward is studied. The antenna properties are analyzed and compact antenna design is determined based on the simulation results. The dresults show the gap between antennas can be optimized to 1 mm while maintaining low mutual coupling. The gain of the MIMO antenna is 8.42 dBi. The simulated return losses, together with the radiation patterns, are presented and discussed.