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Current Status of
Transboundary Animal
Diseases (TADs)
in Taiwan
1
Nien-Nung Lin
Bureau of Animal and Plant Health Inspection and
Quarantine (BAPHIQ), Council of Agriculture, Taiwan
2016.7.27
Outline
• General Aspects
• TADs Status and Control and Prevention
Policy
– FMD
– HPAI
• Conclusion
2
3
General Aspects (1/4)
Species Farm Head
Cattle 2,059 148,147
Goat 2,047 154,710
Pig 7,681 5,498,817
Chicken 5,722 88,140,140
Duck 2,693 7,473,062
Goose 515 641,949
Livestock population in 2016
General Aspects (2/4)
4
• Chickens and pigs are
the main population of
livestock
Above 80% of poultry
and swine population
locates in south-western
part of Taiwan
5
General Aspects (3/4)
The Council of
Agriculture (COA)
The Bureau of Animal and Plant
Health Inspection and Quarantine
(BAPHIQ)
Animal Health
Inspection
Animal
Quarantine
Department
Meat Inspection
Department
Planning
Department
Other department
related to plant
health inspection
and quarantine
4 Branch
offices
17 Inspection
stations
22 LDCCs
The Animal Health Research
Institute (AHRI)
The Branch Institute of
Animal Drugs Inspection
1 Central authority/
1 National Lab
22 local animal disease
control centers (LDCCs)
 Disease prevention and control
 Central authority: BAPHIQ (Animal Health Inspection)
 Local authorities: LDCCs
 Quarantine
 BAPHIQ (Animal Quarantine Department, Branch offices and Inspection stations )
6
General Aspects (4/4)
The organizational chart of the official veterinary services and
the chain of command
TADs-FMD Status(1/3)
• Devastating outbreaks in 1997
– Serotype O
– Cathay topotype FMDV (Pig adopted strain )
• the predominated FMDV till now
– Pigs
• Outbreaks of the new strain in 1999-2000
– In Kinmen county
– Serotype O
– Pan Asia topotype FMDV
– Yellow cattle, diary cattle and goats
• Sporadic outbreaks were reported in 1998-
2001
– O-Cathay FMDV
7
TADs-FMD Status(2/3)
• No case was reported and detected from 2002 to 2008
• 2009-2016:
– O-Cathay FMDV (predominated)
– O-SEA FMDV invaded in 2012 (Kinmen county)
– A-SEA 97 FMDV invaded in 2015 (Kinmen county)
• No case was detected/ observed from June 2013 to
April 2015
NSP case: NSP(+), Ag PCR(-) and VI(-)
Viral case: NSP(-), Ag PCR(+) or VI(+)
Year
Cases Cases
NSPa Viralb Total
2009 5 3 8
2010 3 1 4
2011 7 4 11
2012 10 5 15
2013 3 0 3
2014 0 0 0
2015 1 1 2
Total 29 14 43
8
TADs-FMD Status(3/3)
• Offshore island is in high risk of FMD
outbreak, especially in Kinmen county
– 1999: O-MESA FMDV
– 2012: O-SEA FMDV
– 2015: A FMDV
Kinmen
county
PR China
Taiwan
9
FMD Control and Prevention
Policy
• Regulations
 Statute for Prevention and Control of Infectious
Animal Disease
 Regulations on management of compulsory
vaccination for HC and FMD Elimination
 Regulations on Cleaning and Disinfection of
Animal Transportation Vehicles and Cages
10
FMD Control Policy
• Blanket vaccination
• Surveillance
– Evaluation of vaccination efficacy (SN titer)
– Detection of any suspect case
• Clinical signs
• NSP Ab
• Preventive measures
• Case control
• Stockpile vaccines of other serotypes of
FMDV for emergency use
11
Blanket Vaccination
• Blanket vaccination
– All cloven-hoofed animals shall be vaccinated
with FMD vaccine
– O Taiwan and O Campos strain vaccines (at
least 6 PD50) are used (IM route)
12
Blanket Vaccination
• Anti-violation operation is conducted by
the verification team on daily basis 13
Pig
Birth vaccination booster ………….
Age 0d 12wk 14wk 6m 9m 12m
Birth 1st vaccination 2st vaccination booster ….
Age 0D 4m 12m 2y
Ruminant
Blanket Vaccination
• Penalty:
– The owner or keeper will be fined by NTD 30,000-
150,000 (USD 1,000-5,000) when
• violation of compulsory vaccination, or
• all tested animals with titers of FMD SN antibodies ≦4
– The owner or keeper shall make a booster to
animals kept in the farm when
• mean titer of FMD SN antibodies from tested pigs is <16
(ruminant animal <32)
– The boosted herd shall be re-tested after 3-5
weeks to ensure herd level protection 14
Surveillance
• Active surveillance
– SN titer
• evaluating the efficacy of blanket vaccination
• SN mean titer value for herd level protection
– ≧16x in pigs.
– ≧ 32x in ruminants.
• The testing results below the standard values link to the
corresponding penalty.
– NSP antibody
• to detect possible viral activity in the field.
15
Surveillance
• On-farm active surveillance
– Clinical inspection
– Serological testing
• Random sampling
– 95% confidence level, 1% prevalence
– 600 pig farms/year
– 300 ruminant farms/year
» 15 serum samples/farm
• Target Sampling
– 800 pig farms/year
– 160 ruminant farms/year
– The achievements in 2015
• Above 80% of tested cloven-hoofed animal farms
had protective SN titer 16
Surveillance
• Meat markets surveillance
– Clinical inspection
– Serological testing for NSP antibody on daily
basis
• 1-2 animals per original farm
• 40 thousands samples/year
– Any suspected case shall be traced back to the
original farm to conduct
• movement restriction
• follow-up clinical inspection, serological and virological
sampling
17
Surveillance
18
Prevention Measures
• Application of biosecurity principles at the
farm level
– On and off farm control
– Personal and vehicle biosecurity
– Routine cleaning and disinfection
– Selective purchasing and quarantine
– Self monitoring and reporting the suspect case
19
Prevention Measures
• Application of vehicles control,
transportation vehicle and establishment
disinfection at auction markets and
slaughterhouses
– Supervised by LDCCs and veterinary meat
inspectors
• Awareness program and education on
farmers and stakeholders
20
Case Control
– Movement restriction on the infected farm
– Culling of clinically infected animals and their pen
mates (exposed animals)
– Disposal of carcasses
– Vaccination of healthy animals within the infected
farm to improve the herd level protection.
– Surveillance on surrounding cloven-hoofed
animal farms within 3 km radius area around the
infected farm.
21
Stockpile for Emergency Use of
Other Serotype of FMDV
• Commercial vaccines:
– Serotype: A, Asia-1 and O
– Monovalent
– 100,000 doses/ each serotype (A and
Asia-1)
– 50,000 doses/ O serotype
• Antigen bank:
– Serotype: A and Asia-1
– Monovalent
– 600,000 doses/ each serotype
22
23
TADs- HPAI Status (1/3)
• Active surveillance program has started
since 1998
– Poultry farm: about 1,000 farms/year
– Wild birds: more than 3,000 dropping samples
from wetlands/year
– Total (include pet bird):over 25,000
samples/year
• No H5N1, H5N8, novel H5N2, novel H5N3
subtypes HPAI nor H7N9 (China) subtypes
LPAI have been detected before 2015
TADs- HPAI Status (2/3)
• High Pathogenicity Avian Influenza (HPAI)
– Novel H5N2, H5N3 and H5N8 were confirmed in
2015
– 6 basic amino acids in their HA cleavage site, which
have never been detected in Taiwan before and are
approximately 98%~99% identical to the H5 gene of
the 2014 Korean H5N8 HPAIV.
– HPAI Status
• 2015: 224Chicken farms (including Turkey farms), 101
Duck farms, 681 Geese farms and 27 slaughter house cases,
total 1,028 cases, 5,446,814 birds were culled.
• 2016:Up to July. 20, 17 Chicken farms (including Turkey
farms) , 3 Duck farms,14 Geese farms, and 9 slaughter
house cases, total 43 cases, 256,103 birds were culled.
24
TADs- AI Status (3/3)
25
678
182
22 23 18 10 15 4 4 3 6 16
0
22 12 7 5 4 1 5 5 3 1 00 0 0 1 1 1 0 2 1 1 1 0
0
100
200
300
400
500
600
700
800
1 2 3 4 5 6 7 8 9 10 11 12
Farmswithconfirmeddiagnosis
Month
Reporting system Surveillance on surrounding farms of index farm Active surveillance
HPAI Control Policy
• No vaccination policy
• Stamping out
• Active surveillance
– Poultry farms within 1 KM radius of infected farm
– Routine surveillance
• Two nationwide standstill on poultry
movement and slaughtering
• Quarantine stations
• Health Certificate by veterinarian
• Promoting “Regulations on Prevention of
H5/H7 Subtype Avian Influenza” and
“Regulations on Cleaning and Disinfection
of Animal Transportation Vehicle and Cage”26
Achievements in TADs control
• Taiwan, Penghu, Matzu Island have no
FMD case detected or found since June
2013.
• Two yellow cattle cases of A serotype
FMD were found in Kinmen island in
April and June 2015.
• Appling FMD free zone where
vaccination is practiced to the OIE in
2017
• Avian influenza cases have decreased
from 1,054 cases in 2015 into 43 cases in
2016. 27
Conclusion
• Implement of active surveillance and
monitoring the efficacy of vaccination
policy
• Conducting educations, awareness
campaigns, on-site assistances and
incentive measures
• Guide farmers to improve their
hard/software biosecurity measures by
"Regulations on Prevention of H5/H7
Subtype Avian Influenza”
28
Thank you for
your attention!
29

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  • 1. Current Status of Transboundary Animal Diseases (TADs) in Taiwan 1 Nien-Nung Lin Bureau of Animal and Plant Health Inspection and Quarantine (BAPHIQ), Council of Agriculture, Taiwan 2016.7.27
  • 2. Outline • General Aspects • TADs Status and Control and Prevention Policy – FMD – HPAI • Conclusion 2
  • 3. 3 General Aspects (1/4) Species Farm Head Cattle 2,059 148,147 Goat 2,047 154,710 Pig 7,681 5,498,817 Chicken 5,722 88,140,140 Duck 2,693 7,473,062 Goose 515 641,949 Livestock population in 2016
  • 4. General Aspects (2/4) 4 • Chickens and pigs are the main population of livestock Above 80% of poultry and swine population locates in south-western part of Taiwan
  • 5. 5 General Aspects (3/4) The Council of Agriculture (COA) The Bureau of Animal and Plant Health Inspection and Quarantine (BAPHIQ) Animal Health Inspection Animal Quarantine Department Meat Inspection Department Planning Department Other department related to plant health inspection and quarantine 4 Branch offices 17 Inspection stations 22 LDCCs The Animal Health Research Institute (AHRI) The Branch Institute of Animal Drugs Inspection 1 Central authority/ 1 National Lab 22 local animal disease control centers (LDCCs)  Disease prevention and control  Central authority: BAPHIQ (Animal Health Inspection)  Local authorities: LDCCs  Quarantine  BAPHIQ (Animal Quarantine Department, Branch offices and Inspection stations )
  • 6. 6 General Aspects (4/4) The organizational chart of the official veterinary services and the chain of command
  • 7. TADs-FMD Status(1/3) • Devastating outbreaks in 1997 – Serotype O – Cathay topotype FMDV (Pig adopted strain ) • the predominated FMDV till now – Pigs • Outbreaks of the new strain in 1999-2000 – In Kinmen county – Serotype O – Pan Asia topotype FMDV – Yellow cattle, diary cattle and goats • Sporadic outbreaks were reported in 1998- 2001 – O-Cathay FMDV 7
  • 8. TADs-FMD Status(2/3) • No case was reported and detected from 2002 to 2008 • 2009-2016: – O-Cathay FMDV (predominated) – O-SEA FMDV invaded in 2012 (Kinmen county) – A-SEA 97 FMDV invaded in 2015 (Kinmen county) • No case was detected/ observed from June 2013 to April 2015 NSP case: NSP(+), Ag PCR(-) and VI(-) Viral case: NSP(-), Ag PCR(+) or VI(+) Year Cases Cases NSPa Viralb Total 2009 5 3 8 2010 3 1 4 2011 7 4 11 2012 10 5 15 2013 3 0 3 2014 0 0 0 2015 1 1 2 Total 29 14 43 8
  • 9. TADs-FMD Status(3/3) • Offshore island is in high risk of FMD outbreak, especially in Kinmen county – 1999: O-MESA FMDV – 2012: O-SEA FMDV – 2015: A FMDV Kinmen county PR China Taiwan 9
  • 10. FMD Control and Prevention Policy • Regulations  Statute for Prevention and Control of Infectious Animal Disease  Regulations on management of compulsory vaccination for HC and FMD Elimination  Regulations on Cleaning and Disinfection of Animal Transportation Vehicles and Cages 10
  • 11. FMD Control Policy • Blanket vaccination • Surveillance – Evaluation of vaccination efficacy (SN titer) – Detection of any suspect case • Clinical signs • NSP Ab • Preventive measures • Case control • Stockpile vaccines of other serotypes of FMDV for emergency use 11
  • 12. Blanket Vaccination • Blanket vaccination – All cloven-hoofed animals shall be vaccinated with FMD vaccine – O Taiwan and O Campos strain vaccines (at least 6 PD50) are used (IM route) 12
  • 13. Blanket Vaccination • Anti-violation operation is conducted by the verification team on daily basis 13 Pig Birth vaccination booster …………. Age 0d 12wk 14wk 6m 9m 12m Birth 1st vaccination 2st vaccination booster …. Age 0D 4m 12m 2y Ruminant
  • 14. Blanket Vaccination • Penalty: – The owner or keeper will be fined by NTD 30,000- 150,000 (USD 1,000-5,000) when • violation of compulsory vaccination, or • all tested animals with titers of FMD SN antibodies ≦4 – The owner or keeper shall make a booster to animals kept in the farm when • mean titer of FMD SN antibodies from tested pigs is <16 (ruminant animal <32) – The boosted herd shall be re-tested after 3-5 weeks to ensure herd level protection 14
  • 15. Surveillance • Active surveillance – SN titer • evaluating the efficacy of blanket vaccination • SN mean titer value for herd level protection – ≧16x in pigs. – ≧ 32x in ruminants. • The testing results below the standard values link to the corresponding penalty. – NSP antibody • to detect possible viral activity in the field. 15
  • 16. Surveillance • On-farm active surveillance – Clinical inspection – Serological testing • Random sampling – 95% confidence level, 1% prevalence – 600 pig farms/year – 300 ruminant farms/year » 15 serum samples/farm • Target Sampling – 800 pig farms/year – 160 ruminant farms/year – The achievements in 2015 • Above 80% of tested cloven-hoofed animal farms had protective SN titer 16
  • 17. Surveillance • Meat markets surveillance – Clinical inspection – Serological testing for NSP antibody on daily basis • 1-2 animals per original farm • 40 thousands samples/year – Any suspected case shall be traced back to the original farm to conduct • movement restriction • follow-up clinical inspection, serological and virological sampling 17
  • 19. Prevention Measures • Application of biosecurity principles at the farm level – On and off farm control – Personal and vehicle biosecurity – Routine cleaning and disinfection – Selective purchasing and quarantine – Self monitoring and reporting the suspect case 19
  • 20. Prevention Measures • Application of vehicles control, transportation vehicle and establishment disinfection at auction markets and slaughterhouses – Supervised by LDCCs and veterinary meat inspectors • Awareness program and education on farmers and stakeholders 20
  • 21. Case Control – Movement restriction on the infected farm – Culling of clinically infected animals and their pen mates (exposed animals) – Disposal of carcasses – Vaccination of healthy animals within the infected farm to improve the herd level protection. – Surveillance on surrounding cloven-hoofed animal farms within 3 km radius area around the infected farm. 21
  • 22. Stockpile for Emergency Use of Other Serotype of FMDV • Commercial vaccines: – Serotype: A, Asia-1 and O – Monovalent – 100,000 doses/ each serotype (A and Asia-1) – 50,000 doses/ O serotype • Antigen bank: – Serotype: A and Asia-1 – Monovalent – 600,000 doses/ each serotype 22
  • 23. 23 TADs- HPAI Status (1/3) • Active surveillance program has started since 1998 – Poultry farm: about 1,000 farms/year – Wild birds: more than 3,000 dropping samples from wetlands/year – Total (include pet bird):over 25,000 samples/year • No H5N1, H5N8, novel H5N2, novel H5N3 subtypes HPAI nor H7N9 (China) subtypes LPAI have been detected before 2015
  • 24. TADs- HPAI Status (2/3) • High Pathogenicity Avian Influenza (HPAI) – Novel H5N2, H5N3 and H5N8 were confirmed in 2015 – 6 basic amino acids in their HA cleavage site, which have never been detected in Taiwan before and are approximately 98%~99% identical to the H5 gene of the 2014 Korean H5N8 HPAIV. – HPAI Status • 2015: 224Chicken farms (including Turkey farms), 101 Duck farms, 681 Geese farms and 27 slaughter house cases, total 1,028 cases, 5,446,814 birds were culled. • 2016:Up to July. 20, 17 Chicken farms (including Turkey farms) , 3 Duck farms,14 Geese farms, and 9 slaughter house cases, total 43 cases, 256,103 birds were culled. 24
  • 25. TADs- AI Status (3/3) 25 678 182 22 23 18 10 15 4 4 3 6 16 0 22 12 7 5 4 1 5 5 3 1 00 0 0 1 1 1 0 2 1 1 1 0 0 100 200 300 400 500 600 700 800 1 2 3 4 5 6 7 8 9 10 11 12 Farmswithconfirmeddiagnosis Month Reporting system Surveillance on surrounding farms of index farm Active surveillance
  • 26. HPAI Control Policy • No vaccination policy • Stamping out • Active surveillance – Poultry farms within 1 KM radius of infected farm – Routine surveillance • Two nationwide standstill on poultry movement and slaughtering • Quarantine stations • Health Certificate by veterinarian • Promoting “Regulations on Prevention of H5/H7 Subtype Avian Influenza” and “Regulations on Cleaning and Disinfection of Animal Transportation Vehicle and Cage”26
  • 27. Achievements in TADs control • Taiwan, Penghu, Matzu Island have no FMD case detected or found since June 2013. • Two yellow cattle cases of A serotype FMD were found in Kinmen island in April and June 2015. • Appling FMD free zone where vaccination is practiced to the OIE in 2017 • Avian influenza cases have decreased from 1,054 cases in 2015 into 43 cases in 2016. 27
  • 28. Conclusion • Implement of active surveillance and monitoring the efficacy of vaccination policy • Conducting educations, awareness campaigns, on-site assistances and incentive measures • Guide farmers to improve their hard/software biosecurity measures by "Regulations on Prevention of H5/H7 Subtype Avian Influenza” 28
  • 29. Thank you for your attention! 29
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