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On the extended clinical 
workflows for personalized 
healthcare 
Milan Zdravković and Miroslav Trajanović 
Faculty of Mechanical Engineering, University of Niš, Serbia 
International IFIP Working Conference On Enterprise 
Interoperability (IWEI 2013), Enschede, The Netherlands
Electronic Health Record (EHR) 
• “The Electronic Health Record (EHR) is a longitudinal 
electronic record of patient health information 
generated by one or more encounters in any care 
delivery setting. Included in this information are 
patient demographics, progress notes, problems, 
medications, vital signs, past medical history, 
immunizations, laboratory data, and radiology 
reports.”* 
*Health Information Management Systems Society 
Benefits from EHR
Benefits from EHR 
• automation and 
streamlining of the 
clinical workflow 
• evidence-based 
decision support for 
diagnosis or treatment 
prescription (based on 
accurate and complete 
record of a clinical 
patient encounter), 
• support to other care-related 
activities such 
as billing, reporting and 
quality management 
physician assesses the 
effectiveness of treatments 
hospital administrator extracts the 
billing data 
nurse reports a reaction 
researcher analyzes the 
efficiency of medications 
HER and clinical workflow
EHR and clinical workflow 
Treatment management 
Service delivery 
Registration, admissions, 
discharge, and transfer 
(RADT) 
Regist 
ration 
Admis 
sion 
CPOE Entry 
Order Lab 
services 
Order Rad 
services 
Order Pha 
Treatment services 
planning 
Transfer or 
discharge 
Order oth 
services 
EHR 
Master Patient Index - MPI 
Computerized Physician Order Entries (CPOE) 
permit clinical providers to electronically order 
laboratory, pharmacy, and radiology services. 
Each activity is facilitated 
by a relevant system or system 
module 
Each of these systems must 
contribute to EHR 
Virtual Physiological Human
The Virtual Physiological Human 
(VPH) 
• a unifying framework that enables and practically 
benefits from the integration of inter-disciplinary 
data and observations about human’s biology – 
integration of 
– physiological processes across different length and time 
scales 
– descriptive data with predictive models 
– across disciplines 
• aiming at 
– personalized care solutions 
– preventative approach to treatment of diseases 
Custom medical products
Custom medical products 
Motivation and problems
Motivation and problems 
• Manufacturing of the custom medical products is considered 
as one-of-a-kind manufacturing, where the customization 
requirements often affect not only a principal manufacturer 
but also its suppliers. 
• The manufacturing of a custom medical product could also 
include high-tech services by different suppliers, which are 
based on the models which need to be exchanged 
– Typically, some of these services precede supply chain planning phase 
because their results often determine the basic product’s topology. 
• “high complexity of the supply chain planning and execution 
in custom medical products manufacturing”. 
Methodology
Methodology 
• Combine practices of collaborative networked 
organizations with clinical practices 
• Steps 
– Define extended workflow in the context of 
Electronic Health Records (EHR) 
– Identify systems infrastructure and 
interoperability issues 
– Identify models infrastructure 
Extended clinical workflow
Install 
product 
Deliver 
product 
VE’s Resource Planning System 
(VERPS) 
Procedure/Treatment planning 
system (PPS) 
Conceptual product 
design system (PDS) 
VBE’s Resource Planning System 
(VBERPS) 
EHR 
Treatment management 
Service delivery 
Regist 
ration 
Admis 
sion 
Order Lab 
services 
Order Rad 
services 
Order Pha 
services 
Treatment 
planning 
Transfer or 
Order oth discharge 
services 
Order cust 
services 
Proc/Treat 
planning 
Custom prod 
design 
Source 
product 
Manufacture 
product 
Clinical Information System (CIS) 
VE formation 
Extended clinical VBE mngmt VE execution VE dissolution 
workflow (simplified)
VERPS 
VE planning 
system 
VBERPS 
VBE planning 
system 
PDS 
Product design 
system 
PPS 
Procedure 
planning system 
CIS 
Clinical info 
system 
CIS 
Clinical info 
system 
PPS 
Procedure 
planning system 
PDS 
Product design 
system 
VBERPS 
VBE planning 
system 
VERPS 
VE planning 
system 
SSeenndd EEHHRR 
Write 
procedure 
report to EHR; 
Read EHR 
from CIS 
Send 
procedure 
plan 
Read procedure 
features 
CCrreeaattee oorrddeerrss;; 
Send 
procedure 
report 
Associate 
selected 
partners to 
product 
concept 
Report on the 
use of 
resources; 
Request VE 
change 
Write product 
features; 
Annotate 
parametric 
CAD model 
Allocate 
resources for 
procedure 
Supply chain 
model 
VBE 
model 
Product 
model 
Procedure 
model 
EHR 
model 
Systems interoperability issues 
Case study
Case study: Custom orthopedic 
implants manufacturing 
• Made of different types and designs of 
fixtures and scaffolds 
• Associated services 
– Pre-operation planning, digital reconstruction of 
the bone, analysis of biomechanical properties, 
ethical review 
Systems and models infrastructure
N 
I 
SOURCE 
Pre-OP-Sys 
System for 
pre-op planning 
Impl-D-Sys 
Conceptual implant 
design system 
SC-CONF-Sys 
Supply Chain 
configuration system 
Product 
ontology 
Systems and models 
CAD Feature 
ontology 
Configuration 
problem ontology 
Explicit SCOR 
Ontology 
infrastructure 
Implicit SCOR 
Ontology 
Pre-Operation 
process ontology 
Anatomy 
ontology 
CI-Sys 
Clinical information 
system 
EHR 
ontology 
O 
P 
D 
S 
De M 
source-custom- deliver-custom-implant 
plan-part-sourcing 
plan-part-manufacturing 
plan-part-delivery 
plan-services-sourcing 
plan-services-implementation 
plan-services-delivery 
source-scaffold 
source-inner-fixture make-scaffold 
make-inner-fixture 
source-digital-reconstruction 
source-bio-mechanical- 
implement-digital-reconstruction 
analysis 
implement-bio-mechanical- 
analysis 
deliver-digital-reconstruction 
deliver-bio-mechanical- 
analysis 
deliver-scaffold 
make-custom-implant 
deliver-inner-fixture 
implant 
MAKE 
OpenERP-Sys 
Enterprise Resource 
planning system 
Local OpenERP 
ontology 
DELIVER
Thank you for your attention 
Q&A 
Milan Zdravković and Miroslav Trajanović 
Faculty of Mechanical Engineering, University of Niš, Serbia

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On the extended clinical workflows for personalized healthcare

  • 1. On the extended clinical workflows for personalized healthcare Milan Zdravković and Miroslav Trajanović Faculty of Mechanical Engineering, University of Niš, Serbia International IFIP Working Conference On Enterprise Interoperability (IWEI 2013), Enschede, The Netherlands
  • 2. Electronic Health Record (EHR) • “The Electronic Health Record (EHR) is a longitudinal electronic record of patient health information generated by one or more encounters in any care delivery setting. Included in this information are patient demographics, progress notes, problems, medications, vital signs, past medical history, immunizations, laboratory data, and radiology reports.”* *Health Information Management Systems Society Benefits from EHR
  • 3. Benefits from EHR • automation and streamlining of the clinical workflow • evidence-based decision support for diagnosis or treatment prescription (based on accurate and complete record of a clinical patient encounter), • support to other care-related activities such as billing, reporting and quality management physician assesses the effectiveness of treatments hospital administrator extracts the billing data nurse reports a reaction researcher analyzes the efficiency of medications HER and clinical workflow
  • 4. EHR and clinical workflow Treatment management Service delivery Registration, admissions, discharge, and transfer (RADT) Regist ration Admis sion CPOE Entry Order Lab services Order Rad services Order Pha Treatment services planning Transfer or discharge Order oth services EHR Master Patient Index - MPI Computerized Physician Order Entries (CPOE) permit clinical providers to electronically order laboratory, pharmacy, and radiology services. Each activity is facilitated by a relevant system or system module Each of these systems must contribute to EHR Virtual Physiological Human
  • 5. The Virtual Physiological Human (VPH) • a unifying framework that enables and practically benefits from the integration of inter-disciplinary data and observations about human’s biology – integration of – physiological processes across different length and time scales – descriptive data with predictive models – across disciplines • aiming at – personalized care solutions – preventative approach to treatment of diseases Custom medical products
  • 6. Custom medical products Motivation and problems
  • 7. Motivation and problems • Manufacturing of the custom medical products is considered as one-of-a-kind manufacturing, where the customization requirements often affect not only a principal manufacturer but also its suppliers. • The manufacturing of a custom medical product could also include high-tech services by different suppliers, which are based on the models which need to be exchanged – Typically, some of these services precede supply chain planning phase because their results often determine the basic product’s topology. • “high complexity of the supply chain planning and execution in custom medical products manufacturing”. Methodology
  • 8. Methodology • Combine practices of collaborative networked organizations with clinical practices • Steps – Define extended workflow in the context of Electronic Health Records (EHR) – Identify systems infrastructure and interoperability issues – Identify models infrastructure Extended clinical workflow
  • 9. Install product Deliver product VE’s Resource Planning System (VERPS) Procedure/Treatment planning system (PPS) Conceptual product design system (PDS) VBE’s Resource Planning System (VBERPS) EHR Treatment management Service delivery Regist ration Admis sion Order Lab services Order Rad services Order Pha services Treatment planning Transfer or Order oth discharge services Order cust services Proc/Treat planning Custom prod design Source product Manufacture product Clinical Information System (CIS) VE formation Extended clinical VBE mngmt VE execution VE dissolution workflow (simplified)
  • 10. VERPS VE planning system VBERPS VBE planning system PDS Product design system PPS Procedure planning system CIS Clinical info system CIS Clinical info system PPS Procedure planning system PDS Product design system VBERPS VBE planning system VERPS VE planning system SSeenndd EEHHRR Write procedure report to EHR; Read EHR from CIS Send procedure plan Read procedure features CCrreeaattee oorrddeerrss;; Send procedure report Associate selected partners to product concept Report on the use of resources; Request VE change Write product features; Annotate parametric CAD model Allocate resources for procedure Supply chain model VBE model Product model Procedure model EHR model Systems interoperability issues Case study
  • 11. Case study: Custom orthopedic implants manufacturing • Made of different types and designs of fixtures and scaffolds • Associated services – Pre-operation planning, digital reconstruction of the bone, analysis of biomechanical properties, ethical review Systems and models infrastructure
  • 12. N I SOURCE Pre-OP-Sys System for pre-op planning Impl-D-Sys Conceptual implant design system SC-CONF-Sys Supply Chain configuration system Product ontology Systems and models CAD Feature ontology Configuration problem ontology Explicit SCOR Ontology infrastructure Implicit SCOR Ontology Pre-Operation process ontology Anatomy ontology CI-Sys Clinical information system EHR ontology O P D S De M source-custom- deliver-custom-implant plan-part-sourcing plan-part-manufacturing plan-part-delivery plan-services-sourcing plan-services-implementation plan-services-delivery source-scaffold source-inner-fixture make-scaffold make-inner-fixture source-digital-reconstruction source-bio-mechanical- implement-digital-reconstruction analysis implement-bio-mechanical- analysis deliver-digital-reconstruction deliver-bio-mechanical- analysis deliver-scaffold make-custom-implant deliver-inner-fixture implant MAKE OpenERP-Sys Enterprise Resource planning system Local OpenERP ontology DELIVER
  • 13. Thank you for your attention Q&A Milan Zdravković and Miroslav Trajanović Faculty of Mechanical Engineering, University of Niš, Serbia

Editor's Notes

  1. In a way, EHR is the patient specific representation of a clinical workflow, combined with information (from the observations) collected in the course of this workflow. CPOE entries are initially entered according to first patient observations and treatment plan. Once the treatments are launched, namely during and after entered orders execution, it may become necessary to require additional actions, such as pre-operation planning, other tests, etc. When all treatments (in one or multiple iterations) are carried out, the patient is discharged or transferred. All treatments’ results and notes, including the administrative data on the discharge and transfer are added to a patient’s EHR.
  2. These observations may be collected, organized and shared across the laboratories and hospitals, so that clinical and non-clinical experts can collaboratively interpret, model, validate and understand the data. The impact of the VPH on industry will first be felt in the medical device and pharmaceutical industries [1]. The prediction sets an interesting assumption that the knowledge relevant to VPH will be integrated faster across the boundaries of all organizations involved in a healthcare (including hospitals, clinical centers, as well as pharmaceutical and manufacturing industries), than within the clinical centers. The prediction is argued by the global distribution of innovation interest and knowledge and developing trend in providing personalized healthcare, which is often related to customization of the medical products.
  3. standard bone implants are sometimes not sufficient because of abnormal joint anatomy or possible risks of postoperative complications [10], such as aseptic loosening which occurs due to uneven stress distribution on the bone surface.
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